Deoxynyboquinone

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Deoxynyboquinone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

96748-86-6

Deoxynyboquinone 是NQO1的底物，是有效的抗癌剂。Deoxynyboquinone 诱导癌症细胞凋亡 (apoptosis)。Deoxynyboquinone 通过氧化应激和活性氧 (ROS) 的形成杀死癌细胞。

生物活性

Deoxynyboquinone, an excellentNQO1substrate, is a potent antineoplastic agent. Deoxynyboquinone inducesapoptosisincancercell lines. Deoxynyboquinone killscancercells through oxidative stress andreactive oxygen species(ROS) formation^[1]^[2]^[3].

IC₅₀& Target

Apoptosis^[2]^[3]; ROS^[4]

体外研究
(In Vitro)

Deoxynyboquinone (DNQ; 72h) potently induces the death of cancer cells (SK-MEL-5, MCF-7, HL-60, HL-60/ADR) in culture, with IC₅₀values between 16 and 210 nM^[2].
Deoxynyboquinone is still able to induce cancer cell death under hypoxic conditions (HeLa cell; IC₅₀: 5.1 μM)^[2].
Deoxynyboquinone (group B1; 0.5 μM; 3, 6, 24 hours) potently induces apoptosis in cancer cell lines (MCF-7, HL-60) through cytochrome c release^[3].

体内研究
(In Vivo)

Deoxynyboquinone (2.5, 5, and 10 mg/kg; every other day for 5 injections; i.v. for day 2-18) shows antitumor efficacy confirmed by overall survival (at 5 mg/kg), at a 6-fold lower dose than β-lapachone (30 mg/kg)^[4].

分子量

284.27

性状

Solid

Formula

C₁₅H₁₂N₂O₄

CAS 号

96748-86-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 4 mg/mL(14.07 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.5178 mL	17.5889 mL	35.1778 mL
5 mM	0.7036 mL	3.5178 mL	7.0356 mL
10 mM	0.3518 mL	1.7589 mL	3.5178 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。