CPUL1

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CPUL1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2043660-80-4

CPUL1 是一种TrxR抑制剂，对 A549 细胞显示出增殖抑制和抗转移活性。CPUL1 通过抑制TrxR1酶活性来诱导 ROS 介导的ERK/JNK信号传导从而影响上皮-间质转化 (EMT)。CPUL1 与 α-Lipoic Acid (HY-N0492) 或 Dithiodipropionic acid (HY-W014395) 联合使用效果更好。

生物活性

CPUL1 is aTrxRinhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediatedERK/JNKsignaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination withα-Lipoic Acid(HY-N0492) orDithiodipropionic acid(HY-W014395) is more effective^[1].

体外研究
(In Vitro)

CPUL1 (2.5, 5, 10, 20, 40 μM; 48 h) inhibits A549 cell proliferation and (2, 4, 8 μM; 48 h) colony formation^[1].
CPUL1 (4, 8 μM; 0, 24, 48 h) inhibits A549 cells migration and (2, 4, 8 μM; 48 h) invasion^[1].
CPUL1 hinders EMT (epithelial-mesenchymal transition) progress and affects MAPK pathway in A549 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	A549 cells
Concentration:	2.5, 5, 10, 20, 40 μM
Incubation Time:	48 h
Result:	Showed a dose-dependent cytotoxicity, with an IC₅₀value of 7.61 μM.

Cell Viability Assay^[1]

Cell Line:	A549 cells
Concentration:	2, 4, 8 μM
Incubation Time:	48 h
Result:	Significantly abolished the capacity of A5459 cells to form colonies at the dose-dependent concentration.

Cell Migration Assay^[1]

Cell Line:	A549 cells
Concentration:	4, 8 μM
Incubation Time:	0, 24, 48 h
Result:	Inhibited the migration of A549 cells in a dose- and time-dependent manner.

分子量

434.28

Formula

C₂₂H₁₃Cl₂N₅O

CAS 号

2043660-80-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.