GSK2292767

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GSK2292767

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1254036-66-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

GSK2292767 是一种有效和选择性的PI3Kδ的抑制剂，pIC₅₀值为 10.1。GSK2292767 的选择性是其他 PI3K 亚型的 500 倍以上。GSK2292767 可用于呼吸系统疾病的研究。

生物活性

GSK2292767 is a potent and selective inhibitor ofPI3Kδ, with apIC₅₀of 10.1. GSK2292767 showing greater than 500-fold selective over the otherPI3Kisoforms. GSK2292767 can be used for the research of respiratory disease^[1].

IC₅₀& Target^[1]

PI3Kδ

10.1 (pIC₅₀)

体内研究
(In Vivo)

GSK2292767 exhibits high clearance (50 mL/min/kg) in vivo and low oral bioavailability (F< 2%) in a rat PK study^[1].
GSK2292767 (0.01-1 μM) has no effect on QT interval, T_p-e, or QRS and no significant risk of TdP arrhythmias in a rabbit cardiac ventricular wedge assay^[1].
GSK2292767 protects against eosinophil recruitment with an ED₅₀of 35 μg/kg in the brown Norway rat acute OVA model of Th2 driven inflammation in the lungs of rats^[1].

Clinical Trial

分子量

512.58

Formula

C₂₄H₂₈N₆O₅S

CAS 号

1254036-66-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.