(S,R,S)-AHPC-PEG3-N3

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CAS NO:

1797406-80-4

VH032-PEG3-N3
VHL Ligand-Linker Conjugates 8
E3 ligase Ligand-Linker Conjugates 12

(S,R,S)-AHPC-PEG3-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。

生物活性

(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used inPROTACtechnology.

IC₅₀& Target

VHL

体外研究
(In Vitro)

(S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker^[1]^[2].

分子量

645.77

性状

Oil

Formula

C₃₀H₄₃N₇O₇S

CAS 号

1797406-80-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

Ethanol : 100 mg/mL(154.85 mM;Need ultrasonic)

H₂O : ≥ 100 mg/mL(154.85 mM)

DMSO : 50 mg/mL(77.43 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.5485 mL	7.7427 mL	15.4854 mL
5 mM	0.3097 mL	1.5485 mL	3.0971 mL
10 mM	0.1549 mL	0.7743 mL	1.5485 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。