Thalidomide-O-amido-C6-NH2

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CAS NO:

1950635-13-8

Cereblon Ligand-Linker Conjugates 11
E3 Ligase Ligand-Linker Conjugates 25

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。

生物活性

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide basedcereblonligand and a linker, can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target

Cereblon

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

分子量

430.45

Formula

C₂₁H₂₆N₄O₆

CAS 号

1950635-13-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.