Thalidomide-NH-C2-PEG3-OH 是一种 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。用于合成 PROTAC BCL-XL 降解剂 XZ739。
| 生物活性 | Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide basedcereblonligand and a linker used forPROTACBCL-XL degrader XZ739[1]. |
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体外研究
(In Vitro) | XZ739, a CRBN-dependentPROTAC BCL-XL degraderwith aDC50value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediatedapoptosis[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
