Pomalidomide-6-O-CH3

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1547163-08-5

Pomalidomide-6-O-CH3 是一种基于 Pomalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体，用于募集 cereblon 蛋白。Pomalidomide-6-O-CH3 可通过 linker 连接到蛋白质配体上形成 PROTAC。

生物活性

Pomalidomide-6-O-CH3 is the Pomalidomide-basedcereblon(CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to formPROTAC^[1].

IC₅₀& Target^[1]

Cereblon

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

分子量

303.27

Formula

C₁₄H₁₃N₃O₅

CAS 号

1547163-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.