Amino-PEG3-C2-Azido is a PEG-basedPROTAClinker can be used in the synthesis of thePARP1degrader iRucaparib-TP3 (HY-130645)^[1].

Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation^[1].

218.25

Oil

C₈H₁₈N₄O₃

134179-38-7

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)