Boc-NH-PEG4-CH2CH2COOH

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CAS NO:

756525-91-4

Boc-NH-PEG4-CH2CH2COOH 是一种基于PEG 的PROTAC linker，用于合成 PROTAC。Boc-NH-PEG4-CH2CH2COOH 也是一种可降解的 ADC linker，用于合成可降解的抗体偶联药物 (ADC) 的 ADC linker。

生物活性

Boc-NH-PEG4-CH2CH2COOH is a PEG-basedPROTAClinker can be used in the synthesis ofPROTAC^[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavableADC linkerused as a linker forantibody-drug conjugates(ADC)^[2].

IC₅₀& Target

PEGs	Alkyl/ether

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

分子量

365.42

性状

Liquid

Formula

C₁₆H₃₁NO₈

CAS 号

756525-91-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month