Boc-11-aminoundecanoic acid 是基于 Alkyl/ether 结构的 PROTAC linker, 可以用来制备 MS432 (HY-130602)。
| 生物活性 | Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAClinker can be used in the synthesis of MS432 (HY-130602)[1]. |
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体外研究
(In Vitro) | MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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