DER_EDWI9
ID DER_EDWI9 Reviewed; 494 AA.
AC C5BES7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=NT01EI_3165;
OS Edwardsiella ictaluri (strain 93-146).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Edwardsiella.
OX NCBI_TaxID=634503;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146;
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; CP001600; ACR70315.1; -; Genomic_DNA.
DR RefSeq; WP_015872403.1; NC_012779.2.
DR AlphaFoldDB; C5BES7; -.
DR SMR; C5BES7; -.
DR STRING; 67780.B6E78_07490; -.
DR PRIDE; C5BES7; -.
DR EnsemblBacteria; ACR70315; ACR70315; NT01EI_3165.
DR GeneID; 7958683; -.
DR KEGG; eic:NT01EI_3165; -.
DR PATRIC; fig|634503.3.peg.2826; -.
DR HOGENOM; CLU_016077_6_2_6; -.
DR OMA; KFRFLEY; -.
DR OrthoDB; 263682at2; -.
DR Proteomes; UP000001485; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW Ribosome biogenesis.
FT CHAIN 1..494
FT /note="GTPase Der"
FT /id="PRO_1000204036"
FT DOMAIN 3..166
FT /note="EngA-type G 1"
FT DOMAIN 207..380
FT /note="EngA-type G 2"
FT DOMAIN 381..465
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 56..60
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 118..121
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 213..220
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 260..264
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 325..328
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 494 AA; 54983 MW; A672D6BD7B6E4AE0 CRC64;
MIPVVALVGR PNVGKSTLFN RLTRTRDALV ADFPGLTRDR KYGRAEVNGH EFIIIDTGGI
DGTENGVETH MAEQSLMAIE EADIVLFLVD ARDGLLPADE AIARHLRSRD KATFLVANKT
DGIDAEVAVG DFYSLGMGEV HPIAASHGRG VTQLIEDALV PFIPQEAPAP VLSEEEENAA
YWAELEAEAD GEAQEEEEAF DPINQPIKIA IVGRPNVGKS TLTNRILGED RVVVYDMPGT
TRDSIYIPME RDEREYVLID TAGVRKRGKV TDTVEKFSVI KTLQAIEDAN VVLLVIDARQ
GISDQDLSLL GFILNSGRSL VVVVNKWDGL SLEVKEQVKD MLDLRLGFVD FARIHFISAL
HGSGVGNLFE SIQEAYESAT RRVSTAMLTR IMTMAQDDHQ PPMVRGRRVK LKYAHAGGYN
PPIVVIHGNQ VKDLPDSYKR YLMNYFRRSL NVMGTPIRIQ FKEGDNPFAN KRNTLTPNQM
RKRKRLLSHL KKTK
