DER_HELAH
ID DER_HELAH Reviewed; 462 AA.
AC Q17WL7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=Hac_1204;
OS Helicobacter acinonychis (strain Sheeba).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=382638;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sheeba;
RX PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA Gressmann H., Achtman M., Schuster S.C.;
RT "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT host jump from early humans to large felines.";
RL PLoS Genet. 2:1097-1110(2006).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; AM260522; CAJ99959.1; -; Genomic_DNA.
DR RefSeq; WP_011578066.1; NC_008229.1.
DR AlphaFoldDB; Q17WL7; -.
DR SMR; Q17WL7; -.
DR STRING; 382638.Hac_1204; -.
DR PRIDE; Q17WL7; -.
DR EnsemblBacteria; CAJ99959; CAJ99959; Hac_1204.
DR KEGG; hac:Hac_1204; -.
DR eggNOG; COG1160; Bacteria.
DR HOGENOM; CLU_016077_6_2_7; -.
DR OMA; KFRFLEY; -.
DR OrthoDB; 263682at2; -.
DR BioCyc; HACI382638:HAC_RS05190-MON; -.
DR Proteomes; UP000000775; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Repeat; Ribosome biogenesis.
FT CHAIN 1..462
FT /note="GTPase Der"
FT /id="PRO_1000011636"
FT DOMAIN 9..171
FT /note="EngA-type G 1"
FT DOMAIN 201..372
FT /note="EngA-type G 2"
FT DOMAIN 373..457
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 62..66
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 123..126
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 207..214
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 254..258
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 318..321
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 462 AA; 51901 MW; C04A398FDE8DE3C6 CRC64;
MNTSPRTLKT IAILGQPNVG KSSLFNRLAK ERIAITSDFV GTTRDINKRK ITLNGHEVEL
LDTGGMAKDA FLSKEIKAFN LKAAQMSDLI LYVVDGKSIP SDEDIKLFRE IFKINPNCFL
VINKIDNDKE KERSYAFSSF GMPKSFNISV SHNRGISALI DAILDALGLT KIIEQDLDID
ILESLETPNN TEDGNNEEEI IQVGIIGRVN VGKSSLLNVL TQKERSIVSS VAGTTIDPID
ETILVKNQKI CFVDTAGIRH KGKILGIEKY ALERTQKALE KSHIALLVLD VSAPFVELDE
KISSLADKHS LGIILILNKW DIRYAPYEEI MATLKRKFRF LEYAPVITTS CLKTRHIEEI
KHKIIEVYEC FSKRIPTSLL NSVISQATQK HPLPSDGGKL VKVYYATQFA TKPPQISLVM
NRPKALHFSY KRYLINTLRK EFNFLGTPLI INAKDKKSVQ QN
