ID   DER_MYCPN               Reviewed;         449 AA.
AC   P75309;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE   AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN   Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN   OrderedLocusNames=MPN_475; ORFNames=MP366;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC       ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC   -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00195}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00195}.
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DR   EMBL; U00089; AAG34744.1; -; Genomic_DNA.
DR   PIR; S73692; S73692.
DR   RefSeq; NP_110163.1; NC_000912.1.
DR   RefSeq; WP_010874831.1; NC_000912.1.
DR   AlphaFoldDB; P75309; -.
DR   SMR; P75309; -.
DR   IntAct; P75309; 1.
DR   STRING; 272634.MPN_475; -.
DR   EnsemblBacteria; AAG34744; AAG34744; MPN_475.
DR   GeneID; 66608852; -.
DR   KEGG; mpn:MPN_475; -.
DR   PATRIC; fig|272634.6.peg.514; -.
DR   HOGENOM; CLU_016077_6_2_14; -.
DR   OMA; KFRFLEY; -.
DR   BioCyc; MPNE272634:G1GJ3-781-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00195; GTPase_Der; 1.
DR   InterPro; IPR031166; G_ENGA.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR016484; GTP-bd_EngA.
DR   InterPro; IPR032859; KH_dom-like.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   Pfam; PF14714; KH_dom-like; 1.
DR   Pfam; PF01926; MMR_HSR1; 2.
DR   PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 2.
DR   PROSITE; PS51712; G_ENGA; 2.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW   Ribosome biogenesis.
FT   CHAIN           1..449
FT                   /note="GTPase Der"
FT                   /id="PRO_0000179014"
FT   DOMAIN          2..169
FT                   /note="EngA-type G 1"
FT   DOMAIN          180..355
FT                   /note="EngA-type G 2"
FT   DOMAIN          356..440
FT                   /note="KH-like"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   BINDING         8..15
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   BINDING         55..59
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   BINDING         118..121
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   BINDING         186..193
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   BINDING         233..237
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   BINDING         298..301
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ   SEQUENCE   449 AA;  50145 MW;  73BDC1A49AF1F8E5 CRC64;
     MFTVAIIGRP NVGKSSLFNR LIQKPYAIIS DTPNTTRDRI YGVGEWLTRQ IAFIDTGGLI
     SQKTPLQQQI EVQVRAALSQ ANAIIFLVSY QEQISSDDFY VAKVLKKIKD KPILLVVNKS
     ENLKPDAYEP NLQQFYSFGF GQPVCVSASH GIGIGNLMDR LVKDNQLPPY HGSSETNPEV
     RFCVIGKPNV GKSSLINQLV QQNRVLVSDE SGTTRDAIDI PLRVNGQNYL LIDTAGIRRK
     GKIAPGIEAA SYGKTQLAIA RSNIILLMVD GSKPLSEQDE IIGGLAQAAL IPVIILVNKW
     DLVQKDSNTM AKFKKQLQSQ FQHLSFAPIV FISVKNNKRL HTIFEQLQII QEQLTKKIST
     SLLNDVIQQA QLFNQAPLFK GGRLQVTYAV QTHSQTPHFV LFCNDPKFVH FSYARFLENK
     IRESFGFSAV PITLYFKSKN ARIRGVAKT