DER_NEIG2
ID DER_NEIG2 Reviewed; 485 AA.
AC B4RKD2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=NGK_0592;
OS Neisseria gonorrhoeae (strain NCCP11945).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=521006;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCCP11945;
RX PubMed=18586945; DOI=10.1128/jb.00566-08;
RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL J. Bacteriol. 190:6035-6036(2008).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001050; ACF29283.1; -; Genomic_DNA.
DR RefSeq; WP_010357432.1; NC_011035.1.
DR PDB; 6XRS; X-ray; 2.80 A; A/B/C/D=1-442.
DR PDBsum; 6XRS; -.
DR AlphaFoldDB; B4RKD2; -.
DR SMR; B4RKD2; -.
DR EnsemblBacteria; ACF29283; ACF29283; NGK_0592.
DR GeneID; 66752763; -.
DR KEGG; ngk:NGK_0592; -.
DR HOGENOM; CLU_016077_6_2_4; -.
DR OMA; KFRFLEY; -.
DR OrthoDB; 263682at2; -.
DR Proteomes; UP000002564; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 1: Evidence at protein level;
KW 3D-structure; GTP-binding; Nucleotide-binding; Repeat; Ribosome biogenesis.
FT CHAIN 1..485
FT /note="GTPase Der"
FT /id="PRO_1000099142"
FT DOMAIN 3..167
FT /note="EngA-type G 1"
FT DOMAIN 176..349
FT /note="EngA-type G 2"
FT DOMAIN 350..434
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT REGION 435..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 56..60
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 119..122
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 182..189
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 229..233
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 294..297
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 15..22
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 36..38
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 47..50
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 53..56
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 57..60
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 74..82
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 83..91
FT /evidence="ECO:0007829|PDB:6XRS"
FT TURN 92..94
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 98..108
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 114..119
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 128..131
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 132..136
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 141..143
FT /evidence="ECO:0007829|PDB:6XRS"
FT TURN 146..148
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 152..160
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 177..181
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 188..196
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 215..220
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 223..228
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 248..257
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 259..266
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 273..284
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 288..294
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 296..298
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 301..314
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 316..318
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 323..325
FT /evidence="ECO:0007829|PDB:6XRS"
FT TURN 328..331
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 337..348
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 354..367
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 379..387
FT /evidence="ECO:0007829|PDB:6XRS"
FT TURN 388..391
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 392..399
FT /evidence="ECO:0007829|PDB:6XRS"
FT HELIX 405..419
FT /evidence="ECO:0007829|PDB:6XRS"
FT STRAND 427..431
FT /evidence="ECO:0007829|PDB:6XRS"
SQ SEQUENCE 485 AA; 53956 MW; C9141A08B63A57FD CRC64;
MKPTIALIGR PNVGKSTLFN RLTRTKDALV HDLPGLTRDR HYGHGKVGSK PYFVIDTGGF
EPVVDSGILH EMAKQTLQAV DEADAVVFLV DGRTGLTPQD KIIADRLRQS PRPVYLAVNK
GEGGDRAVLA AEFYELALGE PHVISGAHGD GVYYLIEEIL ENFPEPEAEE ADAKHPVFAV
IGRPNVGKST LVNAILGEKR VIAFDMAGTT RDSIHIDFER EGKPFTIIDT AGVRRRGKVD
EAVEKFSVIK AMQAVEAANV AVLVLDAQQD IADQDATIAG FALEAGRALV VAVNKWDGIS
EERREQVKRD ISRKLYFLDF AKFHFISALK ERGIDGLFES IQAAYNAAMI KMPTPKITRV
LQTAVGRQQP PRAGLVRPKM RYAHQGGMNP PVIVVHGNSL HAISDSYTRY LTQTFRKAFN
LQGTPLRIQY NVSENPYENA EDKPKKKPLR RVSLSNRIEK REGRKEEKNR FKKKTKVSVK
KQFSK
