ID   AC_BPT4                 Reviewed;          51 AA.
AC   P18924;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   23-FEB-2022, entry version 64.
DE   RecName: Full=Uncharacterized protein 52.2;
GN   Name=ac; Synonyms=52.2;
OS   Enterobacteria phage T4 (Bacteriophage T4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX   NCBI_TaxID=10665;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3280805; DOI=10.1016/0022-2836(88)90320-8;
RA   Chapman D., Morad I., Kaufmann G., Gait M.J., Jorissen L., Snyder L.;
RT   "Nucleotide and deduced amino acid sequence of stp: the bacteriophage T4
RT   anticodon nuclease gene.";
RL   J. Mol. Biol. 199:373-377(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA   Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT   "Bacteriophage T4 genome.";
RL   Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=9560385; DOI=10.1093/genetics/148.4.1655;
RA   Wang F.J., Ripley L.S.;
RT   "The spectrum of acridine resistant mutants of bacteriophage T4 reveals
RT   cryptic effects of the tsL141 DNA polymerase allele on spontaneous
RT   mutagenesis.";
RL   Genetics 148:1655-1665(1998).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Mutations in the gene confer resistance to
CC       acridine-inhibition of phage development. {ECO:0000269|PubMed:9560385}.
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DR   EMBL; AF158101; AAD42488.1; -; Genomic_DNA.
DR   PIR; S01870; S01870.
DR   RefSeq; NP_049877.1; NC_000866.4.
DR   GeneID; 1258681; -.
DR   KEGG; vg:1258681; -.
DR   Proteomes; UP000009087; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Antibiotic resistance; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..51
FT                   /note="Uncharacterized protein 52.2"
FT                   /id="PRO_0000164914"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   51 AA;  5472 MW;  63FDCB0161A8B569 CRC64;
     MNIAKLLGVI SFICWIVACV LTICIDASSV FSQALAQGMC AYLTFVLLSN D