AD4F1_MOUSE
ID AD4F1_MOUSE Reviewed; 407 AA.
AC Q8BM81; A2A751;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Arylacetamide deacetylase-like 4 family member 1 {ECO:0000305};
DE EC=3.1.1.-;
DE AltName: Full=AADACL4 family member 1 {ECO:0000312|MGI:MGI:2685880};
GN Name=Aadacl4fm1 {ECO:0000312|MGI:MGI:2685880};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28757.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK034567; BAC28757.1; ALT_SEQ; mRNA.
DR EMBL; AL606902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS51366.1; -.
DR RefSeq; NP_941064.2; NM_198662.3.
DR AlphaFoldDB; Q8BM81; -.
DR SMR; Q8BM81; -.
DR STRING; 10090.ENSMUSP00000030328; -.
DR ESTHER; mouse-adcl4; Arylacetamide_deacetylase.
DR MEROPS; S09.968; -.
DR GlyGen; Q8BM81; 1 site.
DR PhosphoSitePlus; Q8BM81; -.
DR PaxDb; Q8BM81; -.
DR PRIDE; Q8BM81; -.
DR DNASU; 381572; -.
DR Ensembl; ENSMUST00000030328; ENSMUSP00000030328; ENSMUSG00000028593.
DR GeneID; 381572; -.
DR KEGG; mmu:381572; -.
DR UCSC; uc008vrh.1; mouse.
DR CTD; 381572; -.
DR MGI; MGI:2685880; Aadacl4fm1.
DR VEuPathDB; HostDB:ENSMUSG00000028593; -.
DR eggNOG; KOG1515; Eukaryota.
DR GeneTree; ENSGT00940000157630; -.
DR HOGENOM; CLU_012494_12_2_1; -.
DR InParanoid; Q8BM81; -.
DR OMA; YLETKHA; -.
DR OrthoDB; 1263520at2759; -.
DR PhylomeDB; Q8BM81; -.
DR TreeFam; TF314978; -.
DR BioGRID-ORCS; 381572; 0 hits in 70 CRISPR screens.
DR PRO; PR:Q8BM81; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BM81; protein.
DR Bgee; ENSMUSG00000028593; Expressed in neural tube mantle layer and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..407
FT /note="Arylacetamide deacetylase-like 4 family member 1"
FT /id="PRO_0000265938"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..407
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT MOTIF 119..121
FT /note="Involved in the stabilization of the negatively
FT charged intermediate by the formation of the oxyanion hole"
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 193
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT ACT_SITE 347
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT ACT_SITE 377
FT /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 407 AA; 46220 MW; 22153AF5490E7CD1 CRC64;
MLYLVGFLLA TVCLLVLGVN VWVLIDHFLT IDVPPSIPHP VKFRILHFCF HLTTTWGHIL
EKMNICSMPQ FFCFLQDSLS SKENHGVFVK DLRFGTIPVR LFRPKAASSK PRRGILFFHG
GGAMIGSLDS HHNLCTFLAR ETDSVLVSVG YRKLPYYHHP SLYHDCINAS IHFLKSLKAY
GIDPSRVVIC GESIGGAAAV VVTQTLLSRT DIPKIRAQVL IYPILQAFYF QSPSHLMHKN
IPFLTKDFMI TCICKYLAID FSWKDAMLTG ACISPSAWKK YEKWLSPDNI PKRFRTTYQP
PESPAPFNEA AYLETKHAMN IDISPLVADD KIIAQLPEAF LVSLHWDIIR DDVLLYKKRL
EDQGVPVTWH HVEDGFHGCI LLFDKKLFSF PCSLNIVNAV VSYIKDL
