DER_THEYD
ID DER_THEYD Reviewed; 448 AA.
AC B5YFX9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=THEYE_A1376;
OS Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87).
OC Bacteria; Nitrospirae; Thermodesulfovibrionia; Thermodesulfovibrionales;
OC Thermodesulfovibrionaceae; Thermodesulfovibrio.
OX NCBI_TaxID=289376;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51303 / DSM 11347 / YP87;
RA Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT "The complete genome sequence of Thermodesulfovibrio yellowstonii strain
RT ATCC 51303 / DSM 11347 / YP87.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; CP001147; ACI21570.1; -; Genomic_DNA.
DR RefSeq; WP_012546282.1; NC_011296.1.
DR RefSeq; YP_002249177.1; NC_011296.1.
DR AlphaFoldDB; B5YFX9; -.
DR SMR; B5YFX9; -.
DR STRING; 289376.THEYE_A1376; -.
DR EnsemblBacteria; ACI21570; ACI21570; THEYE_A1376.
DR KEGG; tye:THEYE_A1376; -.
DR PATRIC; fig|289376.4.peg.1338; -.
DR eggNOG; COG1160; Bacteria.
DR HOGENOM; CLU_016077_6_2_0; -.
DR InParanoid; B5YFX9; -.
DR OMA; KFRFLEY; -.
DR OrthoDB; 263682at2; -.
DR Proteomes; UP000000718; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW Ribosome biogenesis.
FT CHAIN 1..448
FT /note="GTPase Der"
FT /id="PRO_1000099175"
FT DOMAIN 2..171
FT /note="EngA-type G 1"
FT DOMAIN 181..364
FT /note="EngA-type G 2"
FT DOMAIN 365..448
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 8..15
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 58..62
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 123..126
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 187..194
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 234..238
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 305..308
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 448 AA; 51363 MW; 31FDB3A8CE3519E7 CRC64;
MFTVVIVGRP NVGKSTLFNR MIKSDEKIKA ITDKFPGVTR DINYGVAKWD DKEFIVVDTG
GFFPEEKIED IIQKQMLEQI EMAISDADLI IHLLDSKEGL LPDDIETARQ LRQTGKDILW
VVNKIDDPSK LSRIYDFYSI GTEELIPISG ITGYGFDELI DKIIEKIPDT QPVNLEQQNL
PKIAVVGRPN VGKSTIINAL LGKKRMIVSP IPGTTRDTID AICTYYGKKY LLIDTAGIKR
LSYYKKEISQ EIYVERLAYF KALRSIERAD VAILVIDALE GIVNQDQKIA GIVAEQKKGL
IILINKWDLI PANERDKKAK FFTDEIKHKL WFVDYAPYLT VSAIDKTRLT KIFPLIDQIL
EEYSKRVSTS ELNRLFSEKL KDVIMSSHGK ELKFYYITQV NVAPPTFVVF VNDQSAVKQH
HIKFIEKLLR ETFHFKFSPI NIKIKQRK
