ID   DES1_CRIDS              Reviewed;          19 AA.
AC   P86136;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Deserticolin-1 {ECO:0000303|PubMed:18601958};
OS   Crinia deserticola (Desert froglet).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Myobatrachoidea; Myobatrachidae;
OC   Myobatrachinae; Crinia.
OX   NCBI_TaxID=104060;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   AMIDATION AT SER-19, AND DISCUSSION OF SEQUENCE.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:18601958};
RX   PubMed=18601958; DOI=10.1016/j.regpep.2008.06.004;
RA   Jackway R.J., Pukala T.L., Maselli V.M., Musgrave I.F., Bowie J.H., Liu Y.,
RA   Surinya-Johnson K.H., Donnellan S.C., Doyle J.R., Llewellyn L.E.,
RA   Tyler M.J.;
RT   "Disulfide-containing peptides from the glandular skin secretions of
RT   froglets of the genus Crinia: structure, activity and evolutionary
RT   trends.";
RL   Regul. Pept. 151:80-87(2008).
CC   -!- FUNCTION: Has antibacterial activity against the Gram-positive bacteria
CC       L.lactis (MIC=25 uM) and S.uberis (MIC=50 uM). Lacks antibacterial
CC       activity against the Gram-negative bacteria E.cloacae and E.coli, and
CC       against the Gram-positive bacteria B.cereus, E.faecalis, L.innocua,
CC       M.luteus, S.aureus and S.epidermidis. Inhibits the formation of NO by
CC       neuronal nitric oxide synthase with an IC(50) of 2.4 uM.
CC       {ECO:0000269|PubMed:18601958}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18601958}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:18601958}.
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DR   AlphaFoldDB; P86136; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..19
FT                   /note="Deserticolin-1"
FT                   /evidence="ECO:0000269|PubMed:18601958"
FT                   /id="PRO_0000371747"
FT   MOD_RES         19
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000269|PubMed:18601958"
SQ   SEQUENCE   19 AA;  2007 MW;  53D29508611AF849 CRC64;
     GLADFLNKAV GKVVDFVKS