ID   DESM_XENLA              Reviewed;         458 AA.
AC   P23239; Q5D0A8;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Desmin;
GN   Name=des;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2806128; DOI=10.1242/dev.105.2.299;
RA   Herrmann H., Fouquet B., Franke W.W.;
RT   "Expression of intermediate filament proteins during development of Xenopus
RT   laevis. II. Identification and molecular characterization of desmin.";
RL   Development 105:299-307(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Muscle-specific type III intermediate filament essential for
CC       proper muscular structure and function. Plays a crucial role in
CC       maintaining the structure of sarcomeres, inter-connecting the Z-disks
CC       and forming the myofibrils, linking them not only to the sarcolemmal
CC       cytoskeleton, but also to the nucleus and mitochondria, thus providing
CC       strength for the muscle fiber during activity. In adult striated muscle
CC       they form a fibrous network connecting myofibrils to each other and to
CC       the plasma membrane from the periphery of the Z-line structures.
CC       {ECO:0000250|UniProtKB:P17661, ECO:0000250|UniProtKB:P31001}.
CC   -!- SUBUNIT: Homomer. {ECO:0000250|UniProtKB:P17661}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250|UniProtKB:P17661}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P17661}. Cell membrane, sarcolemma
CC       {ECO:0000250|UniProtKB:P17661}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X16842; CAA34740.1; -; mRNA.
DR   EMBL; BC046651; AAH46651.1; -; mRNA.
DR   PIR; A43554; A43554.
DR   RefSeq; NP_001080177.1; NM_001086708.1.
DR   AlphaFoldDB; P23239; -.
DR   SMR; P23239; -.
DR   DNASU; 379869; -.
DR   GeneID; 379869; -.
DR   KEGG; xla:379869; -.
DR   CTD; 379869; -.
DR   Xenbase; XB-GENE-6254678; des.1.S.
DR   OMA; QYNDIAM; -.
DR   OrthoDB; 655109at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 379869; Expressed in muscle tissue and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0014704; C:intercalated disc; ISS:UniProtKB.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; ISS:UniProtKB.
DR   GO; GO:0045109; P:intermediate filament organization; ISS:UniProtKB.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Cytoplasm; Intermediate filament; Membrane;
KW   Muscle protein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02542"
FT   CHAIN           2..458
FT                   /note="Desmin"
FT                   /id="PRO_0000063777"
FT   DOMAIN          96..404
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..96
FT                   /note="Head"
FT   REGION          97..129
FT                   /note="Coil 1A"
FT   REGION          130..139
FT                   /note="Linker 1"
FT   REGION          140..240
FT                   /note="Coil 1B"
FT   REGION          241..256
FT                   /note="Linker 12"
FT   REGION          257..275
FT                   /note="Coil 2A"
FT   REGION          276..283
FT                   /note="Linker 2"
FT   REGION          284..400
FT                   /note="Coil 2B"
FT   REGION          401..458
FT                   /note="Tail"
FT   SITE            342
FT                   /note="Stutter"
SQ   SEQUENCE   458 AA;  52802 MW;  E96167E1D8FDEB74 CRC64;
     MSQSYSSNQR ASSYRRTFGG GSPSFSTRSS FGSKGASSSS VSSRVYQVSR STAAPSLSSF
     RATRVAPVRS SYGADVLDFS LADAMNQEFL QTRTNEKVEL QDLNDRFANY IEKVRYLEQQ
     NQILVAEVNR LKGKEPTRVN ELYEEEMREL RRQVDLVTNQ RARVEVERDN LVDDLQKLKQ
     RLQEEIQLKE DAENNLAAFR GDVDAATLAR IDLERRIESL QEEIAFLKKI HEEEIRELQA
     QFQEQQLQVE IDVSKPDLTA ALRDIRAQYE NIAAKNVAEA EEWYKSKVSD LNQAAKKNND
     AMRQSKQEMM EYRHQIQSYT CEIDALKGTN DSLMRQMRDL EEKFSGEAAG YQDTIGRLEE
     EIRNMKDEMA RHLREYQDLL NVKMALDMEI ATYRKLLEGE ESRITLPIQT FSALSFRETS
     PEQRASEVHT KKTVMIKTIE TRDGEVLSEA SQQHQEIL