ID   DET1_MOUSE              Reviewed;         550 AA.
AC   Q9D0A0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DET1 homolog;
DE   AltName: Full=De-etiolated-1 homolog;
GN   Name=Det1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex,
CC       which is required for ubiquitination and subsequent degradation of
CC       target proteins. The complex is involved in JUN ubiquitination and
CC       degradation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the DCX DET1-COP1 ubiquitin ligase complex at
CC       least composed of RBX1, DET1, DDB1, CUL4A and COP1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DET1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK011666; BAB27766.2; -; mRNA.
DR   EMBL; BC031930; AAH31930.1; -; mRNA.
DR   CCDS; CCDS21375.1; -.
DR   RefSeq; NP_083861.1; NM_029585.3.
DR   RefSeq; XP_017167860.1; XM_017312371.1.
DR   AlphaFoldDB; Q9D0A0; -.
DR   BioGRID; 218085; 2.
DR   DIP; DIP-60464N; -.
DR   IntAct; Q9D0A0; 1.
DR   STRING; 10090.ENSMUSP00000032839; -.
DR   iPTMnet; Q9D0A0; -.
DR   PhosphoSitePlus; Q9D0A0; -.
DR   EPD; Q9D0A0; -.
DR   MaxQB; Q9D0A0; -.
DR   PaxDb; Q9D0A0; -.
DR   PRIDE; Q9D0A0; -.
DR   ProteomicsDB; 277983; -.
DR   Ensembl; ENSMUST00000032839; ENSMUSP00000032839; ENSMUSG00000030610.
DR   GeneID; 76375; -.
DR   KEGG; mmu:76375; -.
DR   UCSC; uc009hxo.1; mouse.
DR   CTD; 55070; -.
DR   MGI; MGI:1923625; Det1.
DR   VEuPathDB; HostDB:ENSMUSG00000030610; -.
DR   eggNOG; KOG2558; Eukaryota.
DR   GeneTree; ENSGT00390000005224; -.
DR   HOGENOM; CLU_036725_1_0_1; -.
DR   InParanoid; Q9D0A0; -.
DR   OMA; AFSYVFF; -.
DR   OrthoDB; 603320at2759; -.
DR   PhylomeDB; Q9D0A0; -.
DR   TreeFam; TF324729; -.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   BioGRID-ORCS; 76375; 9 hits in 74 CRISPR screens.
DR   ChiTaRS; Det1; mouse.
DR   PRO; PR:Q9D0A0; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9D0A0; protein.
DR   Bgee; ENSMUSG00000030610; Expressed in hindlimb stylopod muscle and 176 other tissues.
DR   ExpressionAtlas; Q9D0A0; baseline and differential.
DR   Genevisible; Q9D0A0; MM.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISO:MGI.
DR   GO; GO:0031464; C:Cul4A-RING E3 ubiquitin ligase complex; ISO:MGI.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISO:MGI.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISO:MGI.
DR   GO; GO:0016567; P:protein ubiquitination; ISO:MGI.
DR   GO; GO:0065003; P:protein-containing complex assembly; ISO:MGI.
DR   InterPro; IPR019138; De-etiolated_protein_1_Det1.
DR   PANTHER; PTHR13374; PTHR13374; 1.
DR   Pfam; PF09737; Det1; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..550
FT                   /note="DET1 homolog"
FT                   /id="PRO_0000129027"
SQ   SEQUENCE   550 AA;  63837 MW;  EC5446A27B8DC0D1 CRC64;
     MDHHVSTIKP RRIQNQNVIH RLERRRISSG KAGTHWHQVR VFHQNVFPNF TVVNVEKPPC
     FLRKFSPDGR YFIAFSSDQT SLEIYEYQGC QAAEDLLQGY EGEILSNGND QRSVSIRGRL
     FERFFVLLHI TNVAANGEHL NRECSLFTDD CRCVIVGSAA YLPDEPHPPF YEVYRNSESV
     TPNPRSPLED YSLHIIDLHT GRLCDTRTFK CDKVVLSHNQ GLYLYKNILA ILSVQQQTIH
     VFQVTPEGTF IDVRTIGRFC YEDDLLTVSA VFPEVQRDSQ TGMANPFRDP FINSLKHRLL
     VYLWRRAEQD GSAMAKRRFF QYFDQLRQLR MWKMQLLDEN HLFIKYTSED VVTLRVTDPS
     QASFFVVYNM VTTEVIAVFE NTSDELLELF ENFCDLFRNA TLHSEVQFPC SASSNNFARQ
     IQRRFKDTII NAKYGGHTEA VRRLLGQLPI SAQSYSGSPY LDLSLFSYDD KWVSVMERPK
     TCGDHPIRFY ARDSGLLKFE IQAGLLGRPI NHTVRRLVAF TFHPFEPFAI SVQRTNAEYV
     VNFHMRHCCT