ID   DEUP1_XENTR             Reviewed;         596 AA.
AC   F7DP49;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 2.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Deuterosome assembly protein 1 {ECO:0000250|UniProtKB:Q05D60};
DE   AltName: Full=Coiled-coil domain-containing protein 67;
GN   Name=deup1 {ECO:0000250|UniProtKB:Q05D60}; Synonyms=ccdc67;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24240477; DOI=10.1038/ncb2880;
RA   Zhao H., Zhu L., Zhu Y., Cao J., Li S., Huang Q., Xu T., Huang X., Yan X.,
RA   Zhu X.;
RT   "The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for
RT   vertebrate multiciliogenesis.";
RL   Nat. Cell Biol. 15:1434-1444(2013).
CC   -!- FUNCTION: Key structural component of the deuterosome, a structure that
CC       promotes de novo centriole amplification in multiciliated cells.
CC       Deuterosome-mediated centriole amplification occurs in terminally
CC       differentiated multiciliated cells and can generate more than 100
CC       centrioles. Probably sufficient for the specification and formation of
CC       the deuterosome inner core. {ECO:0000269|PubMed:24240477}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to the
CC       deuterosome. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Decreased skin multicilia formation in embryos.
CC       {ECO:0000269|PubMed:24240477}.
CC   -!- SIMILARITY: Belongs to the CEP63 family. {ECO:0000305}.
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DR   EMBL; AAMC01100161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F7DP49; -.
DR   SMR; F7DP49; -.
DR   PaxDb; F7DP49; -.
DR   PRIDE; F7DP49; -.
DR   Ensembl; ENSXETT00000037319; ENSXETP00000037319; ENSXETG00000017121.
DR   eggNOG; ENOG502QRBJ; Eukaryota.
DR   HOGENOM; CLU_073230_0_0_1; -.
DR   InParanoid; F7DP49; -.
DR   TreeFam; TF330595; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017121; Expressed in testis and 7 other tissues.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098536; C:deuterosome; ISS:UniProtKB.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007099; P:centriole replication; IBA:GO_Central.
DR   GO; GO:0098535; P:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; IMP:UniProtKB.
DR   GO; GO:1903251; P:multi-ciliated epithelial cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR031470; Cep63/Deup1_N.
DR   InterPro; IPR029611; Deup1.
DR   PANTHER; PTHR18875:SF5; PTHR18875:SF5; 1.
DR   Pfam; PF17045; CEP63; 1.
PE   3: Inferred from homology;
KW   Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..596
FT                   /note="Deuterosome assembly protein 1"
FT                   /id="PRO_0000425207"
FT   REGION          297..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          8..68
FT                   /evidence="ECO:0000255"
FT   COILED          130..180
FT                   /evidence="ECO:0000255"
FT   COILED          227..284
FT                   /evidence="ECO:0000255"
FT   COILED          337..402
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   596 AA;  69022 MW;  215845E4A758AD4D CRC64;
     MFTNIHSIAR NSSCENELEE LMHQIDIMVS HRKVEWEKHV KVLEQKLEAQ DRELTEARNL
     VDEKNHEIGI LCKKLEGVDT AQHEMAQNYE RQLQALKFQL CKLKKSYEKL HFHQEKHQKN
     ENAAQERSRC ELQWLTQKIE EFKARSREWE KQRVFYQDQL KSLDEQRKTL AEKCQLFQKE
     SLSYQEQLSS QKQLQSEAIT NNQSEMRRLR CLLDTSQETI RSDGVIIENL KSTVKEITLS
     RDSLKDENQQ LLQELRRCQK QSQNMEAQLY KAKLELQSCN DLLRVPALEE RQAQKETANL
     ANQKTAQGEE ASFQVTDPRM NYMTSEPEHK SFNLSKSEKY QAENDLHGTE AKNSDLERLR
     KDIGDLTAKL NQKDVTIATV SRKVSRLERE LELKGAQNRQ TSMPLSQKDV IAELESEMPQ
     IHAVNKAPQT DSGEVDPWIS IKCGEHDKPQ KHRSFHGENN SLKPTNYADT RNHSVGSEWE
     SEKSLCPWNT PTLGSATDDD CDLVDNENEW LSLYNSTLYP GLDLPPISYA CDQLKDSTNS
     SLAGSSLISA AEKFLLEETR RASDFEKILN SHIEEMKRNS ESTVSRYQSH GQSRHI