ID   DEVR_ASPFC              Reviewed;         525 AA.
AC   B0XU60;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Basic helix-loop-helix transcription factor devR {ECO:0000303|PubMed:27393422};
GN   Name=devR {ECO:0000303|PubMed:30914505}; ORFNames=AFUB_030440;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RX   PubMed=27393422; DOI=10.1111/mmi.13462;
RA   Valiante V., Baldin C., Hortschansky P., Jain R., Thywissen A.,
RA   Strassburger M., Shelest E., Heinekamp T., Brakhage A.A.;
RT   "The Aspergillus fumigatus conidial melanin production is regulated by the
RT   bifunctional bHLH DevR and MADS-box RlmA transcription factors.";
RL   Mol. Microbiol. 102:321-335(2016).
RN   [3]
RP   INDUCTION.
RX   PubMed=30914505; DOI=10.1128/mbio.00215-19;
RA   Manfiolli A.O., Siqueira F.S., Dos Reis T.F., Van Dijck P., Schrevens S.,
RA   Hoefgen S., Foege M., Strassburger M., de Assis L.J., Heinekamp T.,
RA   Rocha M.C., Janevska S., Brakhage A.A., Malavazi I., Goldman G.H.,
RA   Valiante V.;
RT   "Mitogen-activated protein kinase cross-talk interaction modulates the
RT   production of melanins in Aspergillus fumigatus.";
RL   MBio 10:0-0(2019).
CC   -!- FUNCTION: Fungal-specific basic helix-loop-helix (bHLH) transcription
CC       factor involved in the activation of the dihydroxynaphthalene (DHN)-
CC       melanin pathway (PubMed:27393422). Specifically recognizes DNA binding
CC       sites (E-boxes) identified in the promoter sequence of the gene coding
CC       for the polyketide synthase pksP (PubMed:27393422).
CC       {ECO:0000269|PubMed:27393422}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27393422}.
CC       Note=Localization to the nucleus is increased by external KCl.
CC       {ECO:0000269|PubMed:27393422}.
CC   -!- INDUCTION: Expression is inceased 10 to 15 fold when the MAPK mpkB is
CC       deleted. {ECO:0000269|PubMed:30914505}.
CC   -!- DISRUPTION PHENOTYPE: Affects sporulation and reduces the expression of
CC       the DHN-melanin gene cluster. {ECO:0000269|PubMed:27393422}.
CC   -!- SIMILARITY: Belongs to the MAX family. {ECO:0000305}.
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DR   EMBL; DS499595; EDP54983.1; -; Genomic_DNA.
DR   EnsemblFungi; EDP54983; EDP54983; AFUB_030440.
DR   HOGENOM; CLU_017046_1_0_1; -.
DR   PhylomeDB; B0XU60; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR037933; MAX-like.
DR   PANTHER; PTHR10328; PTHR10328; 2.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..525
FT                   /note="Basic helix-loop-helix transcription factor devR"
FT                   /id="PRO_0000454891"
FT   DOMAIN          371..422
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..384
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          385..422
FT                   /note="Helix-loop-helix motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          443..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..460
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  56987 MW;  EBD7B9023F42DEBC CRC64;
     METTLTHRPW EPTTTGPQNA PTSSAQTLPS ISTLTASMAS NIPLPAEKSP GNASLNTVER
     DSGNWSMPQS TSMISCSTSA MPGTDSLPGS STYSTATNGT GNYPSLSFLT SSQPSPNRGS
     VSERSPYPND HSSTNTPSSA GAHPSPNFGS QTNPTLPSLN QNFDAPSQRG SIAEPPESRR
     SSVDSRMNQG ISSLAINPAS PYHSTNASQT SIVSGLQRER GISMDVNMNN SYRGPRYSGT
     QPLSPLGPRA GEHRSFAAGR TAPAISSNPR SEIYAAETPT AGLAYAFPDP DVARSNSMSS
     TNDKSQHPFS RKGSTAESLA SSIYSDARLP RGQHELPQNV HHHTLQHKQV RDLIGDPEPP
     TSSTPYSRTP ELRVTHKLAE RKRRSEMKDC FEALRMRLPQ SQNNKSSKWE TLTRAIEYIG
     QLEKMLSNAR RENDVLRSEV EEMRAQLNQQ QQQQAHQHSR PPSIFEHHPM NGPQANGQSH
     GPGPAFSNYG PNSSTMMQEQ PRTLPPLVNG PVAPMQGVQY TDDRR