ID   DEVR_MYXXD              Reviewed;         302 AA.
AC   Q07765; Q1CW48;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=CRISPR-associated protein Cas7/Cst2/DevR;
DE   AltName: Full=CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/Tneap;
DE   AltName: Full=Fruiting body developmental protein R;
GN   Name=devR; Synonyms=cas7; OrderedLocusNames=MXAN_7262;
OS   Myxococcus xanthus (strain DK1622).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=DK1622;
RX   PubMed=7693658; DOI=10.1128/jb.175.22.7450-7462.1993;
RA   Thoeny-Meyer L., Kaiser D.;
RT   "devRS, an autoregulated and essential genetic locus for fruiting body
RT   development in Myxococcus xanthus.";
RL   J. Bacteriol. 175:7450-7462(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK1622;
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA   Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA   Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA   Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
RN   [3]
RP   INDUCTION, AND OPERON STRUCTURE.
RC   STRAIN=DK1622;
RX   PubMed=17369305; DOI=10.1128/jb.00187-07;
RA   Viswanathan P., Murphy K., Julien B., Garza A.G., Kroos L.;
RT   "Regulation of dev, an operon that includes genes essential for Myxococcus
RT   xanthus development and CRISPR-associated genes and repeats.";
RL   J. Bacteriol. 189:3738-3750(2007).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Has a role in fruiting body development, sporulation and
CC       aggregation.
CC   -!- DEVELOPMENTAL STAGE: Operon expression begins by 6 hours after
CC       starvation has initiated development and is under strong negative
CC       autoregulation.
CC   -!- INDUCTION: Part of an operon going from at least MXAN_7266 to MXAN_7259
CC       that includes a CRISPR operon with transcription continuing into the
CC       pre-crRNA locus. {ECO:0000269|PubMed:17369305,
CC       ECO:0000269|PubMed:7693658}.
CC   -!- DISRUPTION PHENOTYPE: Essential for sporulation, decreases sporulation
CC       100 to 1000-fold, aggregation is defective.
CC       {ECO:0000269|PubMed:7693658}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas7/Cst2/DevR
CC       family. Subtype I-B/Tneap subfamily. {ECO:0000305}.
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DR   EMBL; L19029; AAA16134.1; -; Unassigned_DNA.
DR   EMBL; CP000113; ABF86719.1; -; Genomic_DNA.
DR   PIR; B49941; B49941.
DR   RefSeq; WP_011557181.1; NC_008095.1.
DR   AlphaFoldDB; Q07765; -.
DR   STRING; 246197.MXAN_7262; -.
DR   EnsemblBacteria; ABF86719; ABF86719; MXAN_7262.
DR   GeneID; 41364428; -.
DR   KEGG; mxa:MXAN_7262; -.
DR   eggNOG; COG1857; Bacteria.
DR   HOGENOM; CLU_076037_0_0_7; -.
DR   OMA; EMHTTEY; -.
DR   OrthoDB; 1098288at2; -.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR016581; Cas7/Cst2/DevR_bac.
DR   InterPro; IPR013414; Cas7/Cst2/DevR_sub_I-B/Tneap.
DR   InterPro; IPR010154; CRISPR-assoc_Cas7/Cst2/DevR.
DR   Pfam; PF01905; DevR; 1.
DR   PIRSF; PIRSF011362; Fruiting_body_devlp_DevR; 1.
DR   TIGRFAMs; TIGR02585; cas_Cst2_DevR; 1.
DR   TIGRFAMs; TIGR01875; cas_MJ0381; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Fruiting body; Reference proteome; Sporulation.
FT   CHAIN           1..302
FT                   /note="CRISPR-associated protein Cas7/Cst2/DevR"
FT                   /id="PRO_0000079871"
SQ   SEQUENCE   302 AA;  32470 MW;  0A1CFD0D514A3161 CRC64;
     MSLHVFAAFV TPLGTAANNR GLTEGNITSL QKLVWNGQVH TTVSAESIRF ALRRRLNEQE
     PCNRTYDDAS RANAWKDAAF SAWSGKSKEK TYIDDDLLGF MSAEGAKQEK EKGTAKVRRA
     VLEVSRAVSL TPWSGDVTFN AASPGATPSA QKKGSNPVPY GTEMHATRYQ YGVALTPEAL
     RVPARAVTAL NQLCALGPVA GNHGRFLFDF SPESVVFRLT QEAAPRILYA FEPSSRAGGV
     ELAALLRKVK SGDVPAKELV LGGQVVEGLG AEEREVLSGA ELHTGVVAAC RAACKRLEVR
     KK