DEXI_HUMAN
ID DEXI_HUMAN Reviewed; 95 AA.
AC O95424; B2RAA7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Dexamethasone-induced protein;
DE AltName: Full=Protein MYLE;
GN Name=DEXI; Synonyms=MYLE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC TISSUE=Lung;
RX PubMed=11472984; DOI=10.1165/ajrcmb.25.1.4417;
RA Edgar A.J., Birks E.J., Yacoub M.H., Polak J.M.;
RT "Cloning of dexamethasone-induced transcript: a novel glucocorticoid-
RT induced gene that is upregulated in emphysema.";
RL Am. J. Respir. Cell Mol. Biol. 25:119-124(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, Kidney, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O95424; O95393: BMP10; NbExp=3; IntAct=EBI-724515, EBI-3922513;
CC O95424; Q92993: KAT5; NbExp=3; IntAct=EBI-724515, EBI-399080;
CC O95424; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-724515, EBI-11742507;
CC O95424; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-724515, EBI-981985;
CC O95424; P17252: PRKCA; NbExp=3; IntAct=EBI-724515, EBI-1383528;
CC O95424; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-724515, EBI-9090795;
CC O95424; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-724515, EBI-744081;
CC O95424; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-724515, EBI-10243654;
CC O95424; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-724515, EBI-741480;
CC O95424; P61981: YWHAG; NbExp=3; IntAct=EBI-724515, EBI-359832;
CC -!- TISSUE SPECIFICITY: Highest levels in heart. Also expressed in brain,
CC liver, pancreas, placenta and lung. Up-regulated in emphysematous lung
CC compared to normal lung. {ECO:0000269|PubMed:11472984}.
CC -!- INDUCTION: By dexamethasone. {ECO:0000269|PubMed:11472984}.
CC -!- SIMILARITY: Belongs to the DEXI family. {ECO:0000305}.
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DR EMBL; AF108145; AAC83382.2; -; mRNA.
DR EMBL; AK314111; BAG36804.1; -; mRNA.
DR EMBL; CH471112; EAW85167.1; -; Genomic_DNA.
DR EMBL; BC001083; AAH01083.2; -; mRNA.
DR EMBL; BC037569; AAH37569.1; -; mRNA.
DR EMBL; BC052989; AAH52989.1; -; mRNA.
DR EMBL; BC071683; AAH71683.1; -; mRNA.
DR CCDS; CCDS10545.1; -.
DR RefSeq; NP_054734.2; NM_014015.3.
DR RefSeq; XP_016878660.1; XM_017023171.1.
DR AlphaFoldDB; O95424; -.
DR BioGRID; 118782; 5.
DR IntAct; O95424; 13.
DR STRING; 9606.ENSP00000330509; -.
DR BioMuta; DEXI; -.
DR PaxDb; O95424; -.
DR PeptideAtlas; O95424; -.
DR PRIDE; O95424; -.
DR Antibodypedia; 11474; 122 antibodies from 21 providers.
DR DNASU; 28955; -.
DR Ensembl; ENST00000331808.5; ENSP00000330509.4; ENSG00000182108.11.
DR Ensembl; ENST00000469379.5; ENSP00000482265.1; ENSG00000182108.11.
DR Ensembl; ENST00000570440.2; ENSP00000493467.1; ENSG00000182108.11.
DR GeneID; 28955; -.
DR KEGG; hsa:28955; -.
DR MANE-Select; ENST00000331808.5; ENSP00000330509.4; NM_014015.4; NP_054734.2.
DR UCSC; uc002dal.4; human.
DR CTD; 28955; -.
DR DisGeNET; 28955; -.
DR GeneCards; DEXI; -.
DR HGNC; HGNC:13267; DEXI.
DR HPA; ENSG00000182108; Low tissue specificity.
DR MIM; 617901; gene.
DR neXtProt; NX_O95424; -.
DR OpenTargets; ENSG00000182108; -.
DR PharmGKB; PA165449964; -.
DR VEuPathDB; HostDB:ENSG00000182108; -.
DR eggNOG; ENOG502S66C; Eukaryota.
DR GeneTree; ENSGT00390000013271; -.
DR HOGENOM; CLU_184633_0_0_1; -.
DR InParanoid; O95424; -.
DR OMA; PIYAQLD; -.
DR OrthoDB; 1373211at2759; -.
DR PhylomeDB; O95424; -.
DR TreeFam; TF338557; -.
DR PathwayCommons; O95424; -.
DR SignaLink; O95424; -.
DR BioGRID-ORCS; 28955; 225 hits in 1037 CRISPR screens.
DR ChiTaRS; DEXI; human.
DR GenomeRNAi; 28955; -.
DR Pharos; O95424; Tbio.
DR PRO; PR:O95424; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; O95424; protein.
DR Bgee; ENSG00000182108; Expressed in apex of heart and 196 other tissues.
DR Genevisible; O95424; HS.
DR InterPro; IPR023259; Dexamethasone-induced.
DR PANTHER; PTHR17070; PTHR17070; 1.
DR Pfam; PF15198; Dexa_ind; 1.
DR PRINTS; PR02032; DEXMETHSNEIP.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..95
FT /note="Dexamethasone-induced protein"
FT /id="PRO_0000096669"
SQ SEQUENCE 95 AA; 10429 MW; F9F98DE2572D3F83 CRC64;
MLGARVAAHL DALGPLVPYV PPPLLPSMFY VGLFFVNVLI LYYAFLMEYI VLNVGLVFLP
EDMDQALVDL GVLSDPGSGL YDADSELDVF DAYLE
