ID   DF144_ARATH             Reviewed;          81 AA.
AC   Q8S8H9; A0MJT0; P82725; Q1PF66;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Defensin-like protein 144;
DE   AltName: Full=Low-molecular-weight cysteine-rich protein 10;
DE            Short=Protein LCR10;
DE   Flags: Precursor;
GN   Name=LCR10; OrderedLocusNames=At2g15535; ORFNames=F9O13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM15218.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia {ECO:0000312|EMBL:AAM15218.1};
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17565583; DOI=10.1111/j.1365-313x.2007.03136.x;
RA   Silverstein K.A.T., Moskal W.A. Jr., Wu H.C., Underwood B.A., Graham M.A.,
RA   Town C.D., VandenBosch K.A.;
RT   "Small cysteine-rich peptides resembling antimicrobial peptides have been
RT   under-predicted in plants.";
RL   Plant J. 51:262-280(2007).
RN   [5] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=11437247; DOI=10.1023/a:1010664704926;
RA   Vanoosthuyse V., Miege C., Dumas C., Cock J.M.;
RT   "Two large Arabidopsis thaliana gene families are homologous to the
RT   Brassica gene superfamily that encodes pollen coat proteins and the male
RT   component of the self-incompatibility response.";
RL   Plant Mol. Biol. 46:17-34(2001).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=15955924; DOI=10.1104/pp.105.060079;
RA   Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT   "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL   Plant Physiol. 138:600-610(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK27943.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC       Sequence=EF182807; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC006248; AAM15218.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06415.1; -; Genomic_DNA.
DR   EMBL; DQ446500; ABE65813.1; -; mRNA.
DR   EMBL; DQ912229; ABK27943.1; ALT_SEQ; mRNA.
DR   EMBL; EF182807; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_565375.1; NM_127114.2.
DR   AlphaFoldDB; Q8S8H9; -.
DR   SMR; Q8S8H9; -.
DR   STRING; 3702.AT2G15535.1; -.
DR   PaxDb; Q8S8H9; -.
DR   PRIDE; Q8S8H9; -.
DR   ProteomicsDB; 223998; -.
DR   EnsemblPlants; AT2G15535.1; AT2G15535.1; AT2G15535.
DR   GeneID; 816046; -.
DR   Gramene; AT2G15535.1; AT2G15535.1; AT2G15535.
DR   KEGG; ath:AT2G15535; -.
DR   Araport; AT2G15535; -.
DR   TAIR; locus:505006246; AT2G15535.
DR   HOGENOM; CLU_2577137_0_0_1; -.
DR   OMA; ADTHALN; -.
DR   OrthoDB; 1636925at2759; -.
DR   PhylomeDB; Q8S8H9; -.
DR   PRO; PR:Q8S8H9; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8S8H9; baseline and differential.
DR   Genevisible; Q8S8H9; AT.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR010851; DEFL.
DR   Pfam; PF07333; SLR1-BP; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Disulfide bond; Fungicide; Plant defense;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..81
FT                   /note="Defensin-like protein 144"
FT                   /id="PRO_0000017252"
FT   DISULFID        30..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   81 AA;  8850 MW;  F07565D4BBACCD82 CRC64;
     MKNSFRFSFT VITTFIICVL VSGAMVNGQC SFPQPVGPNG KCVPKDCKSL CHKKYKGGSI
     CTTGKPNICM CLVCRRRSPE V