DF149_ARATH
ID DF149_ARATH Reviewed; 78 AA.
AC Q8S8H3; P82720; Q8LGD4;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Defensin-like protein 149;
DE AltName: Full=Low-molecular-weight cysteine-rich protein 5;
DE Short=Protein LCR5;
DE Flags: Precursor;
GN Name=LCR5; OrderedLocusNames=At2g28355; ORFNames=T1B3.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM15228.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000312|EMBL:AAM15228.1};
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia {ECO:0000269|PubMed:14593172};
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=11437247; DOI=10.1023/a:1010664704926;
RA Vanoosthuyse V., Miege C., Dumas C., Cock J.M.;
RT "Two large Arabidopsis thaliana gene families are homologous to the
RT Brassica gene superfamily that encodes pollen coat proteins and the male
RT component of the self-incompatibility response.";
RL Plant Mol. Biol. 46:17-34(2001).
RN [6]
RP GENE FAMILY.
RX PubMed=15955924; DOI=10.1104/pp.105.060079;
RA Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL Plant Physiol. 138:600-610(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM67275.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC006283; AAM15228.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08111.1; -; Genomic_DNA.
DR EMBL; BT003997; AAO42036.1; -; mRNA.
DR EMBL; AY084332; AAM67275.1; ALT_INIT; mRNA.
DR RefSeq; NP_565670.1; NM_128395.3.
DR AlphaFoldDB; Q8S8H3; -.
DR SMR; Q8S8H3; -.
DR STRING; 3702.AT2G28355.1; -.
DR PaxDb; Q8S8H3; -.
DR PRIDE; Q8S8H3; -.
DR ProteomicsDB; 224636; -.
DR EnsemblPlants; AT2G28355.1; AT2G28355.1; AT2G28355.
DR GeneID; 817383; -.
DR Gramene; AT2G28355.1; AT2G28355.1; AT2G28355.
DR KEGG; ath:AT2G28355; -.
DR Araport; AT2G28355; -.
DR TAIR; locus:505006277; AT2G28355.
DR HOGENOM; CLU_182511_0_0_1; -.
DR InParanoid; Q8S8H3; -.
DR OMA; NCVAAEC; -.
DR OrthoDB; 1613180at2759; -.
DR PhylomeDB; Q8S8H3; -.
DR PRO; PR:Q8S8H3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8H3; baseline and differential.
DR Genevisible; Q8S8H3; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR010851; DEFL.
DR Pfam; PF07333; SLR1-BP; 1.
PE 3: Inferred from homology;
KW Antimicrobial; Disulfide bond; Fungicide; Plant defense;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..78
FT /note="Defensin-like protein 149"
FT /id="PRO_0000017248"
FT DISULFID 36..77
FT /evidence="ECO:0000250"
FT DISULFID 45..65
FT /evidence="ECO:0000250"
FT DISULFID 50..71
FT /evidence="ECO:0000250"
FT DISULFID 54..73
FT /evidence="ECO:0000250"
FT CONFLICT 8
FT /note="L -> V (in Ref. 4; AAM67275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 78 AA; 8642 MW; 08644304DF8B17B5 CRC64;
MMKKLIQLSF TVMIIFTILV LGVVANEGLG KPKKQCNEIL KQSNCVAAEC DSMCVKKRGK
GAGYCSPSKK CYCYYHCP
