DF181_ARATH
ID DF181_ARATH Reviewed; 122 AA.
AC P82789; A0MJT6; Q1PDQ7;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Defensin-like protein 181;
DE AltName: Full=Low-molecular-weight cysteine-rich protein 80;
DE Short=Protein LCR80;
DE AltName: Full=Plant defensin 3.1;
DE Flags: Precursor;
GN Name=PDF3.1; Synonyms=LCR80; OrderedLocusNames=At5g38330;
GN ORFNames=MSI17.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000305};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17565583; DOI=10.1111/j.1365-313x.2007.03136.x;
RA Silverstein K.A.T., Moskal W.A. Jr., Wu H.C., Underwood B.A., Graham M.A.,
RA Town C.D., VandenBosch K.A.;
RT "Small cysteine-rich peptides resembling antimicrobial peptides have been
RT under-predicted in plants.";
RL Plant J. 51:262-280(2007).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=11437247; DOI=10.1023/a:1010664704926;
RA Vanoosthuyse V., Miege C., Dumas C., Cock J.M.;
RT "Two large Arabidopsis thaliana gene families are homologous to the
RT Brassica gene superfamily that encodes pollen coat proteins and the male
RT component of the self-incompatibility response.";
RL Plant Mol. Biol. 46:17-34(2001).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12447532; DOI=10.1007/s00425-002-0902-6;
RA Thomma B.P.H.J., Cammue B.P., Thevissen K.;
RT "Plant defensins.";
RL Planta 216:193-202(2002).
RN [7]
RP GENE FAMILY.
RX PubMed=15955924; DOI=10.1104/pp.105.060079;
RA Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL Plant Physiol. 138:600-610(2005).
CC -!- FUNCTION: Confers broad-spectrum resistance to pathogens.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
CC -!- CAUTION: Contains 8 disulfide bonds instead of the 4 disulfide bonds,
CC which are conserved features of the family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK27946.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB011481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED94298.1; -; Genomic_DNA.
DR EMBL; DQ447011; ABE66199.1; -; mRNA.
DR EMBL; DQ912235; ABK27946.1; ALT_SEQ; mRNA.
DR EMBL; EF182827; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_198649.2; NM_123194.3.
DR AlphaFoldDB; P82789; -.
DR STRING; 3702.AT5G38330.1; -.
DR PaxDb; P82789; -.
DR PRIDE; P82789; -.
DR ProteomicsDB; 224241; -.
DR EnsemblPlants; AT5G38330.1; AT5G38330.1; AT5G38330.
DR GeneID; 833815; -.
DR Gramene; AT5G38330.1; AT5G38330.1; AT5G38330.
DR KEGG; ath:AT5G38330; -.
DR Araport; AT5G38330; -.
DR TAIR; locus:2173288; AT5G38330.
DR eggNOG; ENOG502SD1Z; Eukaryota.
DR HOGENOM; CLU_158287_1_1_1; -.
DR InParanoid; P82789; -.
DR OMA; NCAVCEE; -.
DR OrthoDB; 1411313at2759; -.
DR PhylomeDB; P82789; -.
DR PRO; PR:P82789; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P82789; baseline and differential.
DR Genevisible; P82789; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; ISS:TAIR.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR039641; LCR.
DR PANTHER; PTHR36788; PTHR36788; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Disulfide bond; Fungicide; Plant defense;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..122
FT /note="Defensin-like protein 181"
FT /id="PRO_0000017304"
FT DISULFID 29..70
FT /evidence="ECO:0000250"
FT DISULFID 36..55
FT /evidence="ECO:0000250"
FT DISULFID 39..64
FT /evidence="ECO:0000250"
FT DISULFID 43..66
FT /evidence="ECO:0000250"
FT DISULFID 76..122
FT /evidence="ECO:0000250"
FT DISULFID 87..107
FT /evidence="ECO:0000250"
FT DISULFID 92..116
FT /evidence="ECO:0000250"
FT DISULFID 96..118
FT /evidence="ECO:0000250"
SQ SEQUENCE 122 AA; 13122 MW; 317369451138883B CRC64;
MERIPSLASL VSLLIIFATV VNQTRASICN DRLGLCDGCD QRCKAKHGPS CESKCDGPVG
MLLCTCTYEC GPTKLCNGGL GNCGESCNEQ CCDRNCAQRY NGGHGYCNTL DDFSLCLCKY
PC
