DF223_ARATH
ID DF223_ARATH Reviewed; 87 AA.
AC Q2V369;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 3.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Defensin-like protein 223;
DE Flags: Precursor;
GN OrderedLocusNames=At5g18407; ORFNames=F20L16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15955924; DOI=10.1104/pp.105.060079;
RA Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL Plant Physiol. 138:600-610(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2V369-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2V369-2; Sequence=VSP_037705;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
CC -!- CAUTION: Lacks 1 of the 4 disulfide bonds, which are conserved features
CC of the family. {ECO:0000305}.
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DR EMBL; AC051626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92555.1; -; Genomic_DNA.
DR RefSeq; NP_001031897.2; NM_001036820.2. [Q2V369-2]
DR AlphaFoldDB; Q2V369; -.
DR SMR; Q2V369; -.
DR PRIDE; Q2V369; -.
DR ProteomicsDB; 224639; -. [Q2V369-1]
DR EnsemblPlants; AT5G18407.1; AT5G18407.1; AT5G18407. [Q2V369-2]
DR GeneID; 3770707; -.
DR Gramene; AT5G18407.1; AT5G18407.1; AT5G18407. [Q2V369-2]
DR KEGG; ath:AT5G18407; -.
DR Araport; AT5G18407; -.
DR TAIR; locus:1009023394; AT5G18407.
DR HOGENOM; CLU_2691157_0_0_1; -.
DR OrthoDB; 1854327at2759; -.
DR PRO; PR:Q2V369; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q2V369; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antimicrobial; Disulfide bond; Fungicide;
KW Plant defense; Reference proteome; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..87
FT /note="Defensin-like protein 223"
FT /id="PRO_0000379715"
FT DISULFID 55..72
FT /evidence="ECO:0000250"
FT DISULFID 58..77
FT /evidence="ECO:0000250"
FT DISULFID 62..79
FT /evidence="ECO:0000250"
FT VAR_SEQ 17..30
FT /note="YFNIIVYVSFSFIG -> C (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_037705"
SQ SEQUENCE 87 AA; 9885 MW; BF925C3A6660C7E4 CRC64;
MKSTIFVLTL LIFVSLYFNI IVYVSFSFIG TSEIVVPSSF KRVEGPVTAA SADFCYKCSR
GCYRRYRRPV FCQGSICRCS SFIDDGY
