DF246_ARATH
ID DF246_ARATH Reviewed; 97 AA.
AC P82624; Q1PFI3; Q5XVH8;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Defensin-like protein 246;
DE AltName: Full=S locus cysteine-rich-like protein 5;
DE Short=Protein SCRL5;
DE Short=SCR-like protein 5;
DE Flags: Precursor;
GN Name=SCRL5; OrderedLocusNames=At1g60987; ORFNames=T7P1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000305};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Torian U., Redman J.C.,
RA Wu H.C., Utterback T., Town C.D.;
RT "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT thaliana from 5' and 3' RACE products.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11437247; DOI=10.1023/a:1010664704926;
RA Vanoosthuyse V., Miege C., Dumas C., Cock J.M.;
RT "Two large Arabidopsis thaliana gene families are homologous to the
RT Brassica gene superfamily that encodes pollen coat proteins and the male
RT component of the self-incompatibility response.";
RL Plant Mol. Biol. 46:17-34(2001).
RN [6]
RP GENE FAMILY.
RX PubMed=15955924; DOI=10.1104/pp.105.060079;
RA Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL Plant Physiol. 138:600-610(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P82624-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P82624-2; Sequence=VSP_019749;
CC -!- TISSUE SPECIFICITY: Flower buds and stems.
CC {ECO:0000269|PubMed:11437247}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
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DR EMBL; AC018908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE33759.1; -; Genomic_DNA.
DR EMBL; AY735544; AAU44414.1; -; mRNA.
DR EMBL; DQ446380; ABE65728.1; -; mRNA.
DR RefSeq; NP_974058.1; NM_202329.3. [P82624-1]
DR AlphaFoldDB; P82624; -.
DR STRING; 3702.AT1G60987.1; -.
DR PaxDb; P82624; -.
DR PRIDE; P82624; -.
DR EnsemblPlants; AT1G60987.1; AT1G60987.1; AT1G60987. [P82624-1]
DR GeneID; 2745838; -.
DR Gramene; AT1G60987.1; AT1G60987.1; AT1G60987. [P82624-1]
DR KEGG; ath:AT1G60987; -.
DR Araport; AT1G60987; -.
DR TAIR; locus:1006230782; AT1G60987.
DR HOGENOM; CLU_174283_0_0_1; -.
DR OMA; RMNINAE; -.
DR OrthoDB; 1503537at2759; -.
DR PhylomeDB; P82624; -.
DR PRO; PR:P82624; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P82624; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR010682; SCRL.
DR PANTHER; PTHR34450; PTHR34450; 1.
DR Pfam; PF06876; SCRL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antimicrobial; Disulfide bond; Fungicide;
KW Plant defense; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..97
FT /note="Defensin-like protein 246"
FT /id="PRO_0000031931"
FT DISULFID 39..96
FT /evidence="ECO:0000250"
FT DISULFID 50..79
FT /evidence="ECO:0000250"
FT DISULFID 58..89
FT /evidence="ECO:0000250"
FT DISULFID 77..91
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..28
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_019749"
SQ SEQUENCE 97 AA; 11119 MW; 66CA0E925B7D8F54 CRC64;
MKFVAIFLVT CVLFSLFPSH LSQGEESRMN INAERRPWCP SKIQMFDTNC EVDGAKQCLD
LLISTWDPSV RLTRVSCICS DFPYRNMMCS CPNMICP
