DFA17_MOUSE
ID DFA17_MOUSE Reviewed; 82 AA.
AC Q64016;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Alpha-defensin 17;
DE AltName: Full=Defensin-related cryptdin-17;
DE Short=CRYP17;
DE Flags: Precursor; Fragment;
GN Name=Defa17; Synonyms=Defcr17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Intestinal crypt;
RX PubMed=7927786; DOI=10.1128/iai.62.11.5040-5047.1994;
RA Ouellette A.J., Hsieh M.M., Nosek M.T., Cano-Gauci D.F., Huttner K.M.,
RA Buick R.N., Selsted M.E.;
RT "Mouse Paneth cell defensins: primary structures and antibacterial
RT activities of numerous cryptdin isoforms.";
RL Infect. Immun. 62:5040-5047(1994).
CC -!- FUNCTION: Probably contributes to the antimicrobial barrier function of
CC the small bowel mucosa.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; S73391; AAB32271.2; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q64016; -.
DR SMR; Q64016; -.
DR PeptideAtlas; Q64016; -.
DR PRIDE; Q64016; -.
DR ProteomicsDB; 279344; -.
DR MGI; MGI:1345152; Defa17.
DR InParanoid; Q64016; -.
DR Reactome; R-MMU-1461973; Defensins.
DR Reactome; R-MMU-1462054; Alpha-defensins.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q64016; protein.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL <1..8
FT /evidence="ECO:0000255"
FT PROPEP 9..47
FT /evidence="ECO:0000250"
FT /id="PRO_0000006847"
FT PEPTIDE 48..82
FT /note="Alpha-defensin 17"
FT /id="PRO_0000006848"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 53..81
FT /evidence="ECO:0000250"
FT DISULFID 55..70
FT /evidence="ECO:0000250"
FT DISULFID 60..80
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 82 AA; 9349 MW; 86350BF483F8F709 CRC64;
LLAFQVQADP IQNTDEETKT EEQPGEEDQA VSVSFGDPEG TSLQEESLRD LVCYCRKRGC
KRREHMNGTC RKGHLLYTLC CR
