DFA23_MOUSE
ID DFA23_MOUSE Reviewed; 93 AA.
AC Q5G866; Q059S0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Alpha-defensin 23;
DE AltName: Full=Defensin-related cryptdin-23;
DE Flags: Precursor;
GN Name=Defa23; Synonyms=Defcr23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15494476; DOI=10.1152/physiolgenomics.00150.2004;
RA Patil A., Hughes A.L., Zhang G.;
RT "Rapid evolution and diversification of mammalian alpha-defensins as
RT revealed by comparative analysis of rodent and primate genes.";
RL Physiol. Genomics 20:1-11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have microbicidal activities. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; AY746428; AAW78337.1; -; mRNA.
DR EMBL; BC125548; AAI25549.1; -; mRNA.
DR EMBL; BC125550; AAI25551.1; -; mRNA.
DR CCDS; CCDS40265.1; -.
DR RefSeq; NP_001012307.1; NM_001012307.2.
DR RefSeq; NP_031874.2; NM_007848.2.
DR AlphaFoldDB; Q5G866; -.
DR SMR; Q5G866; -.
DR STRING; 10090.ENSMUSP00000096495; -.
DR iPTMnet; Q5G866; -.
DR PhosphoSitePlus; Q5G866; -.
DR PaxDb; Q5G866; -.
DR PeptideAtlas; Q5G866; -.
DR PRIDE; Q5G866; -.
DR DNASU; 13226; -.
DR Ensembl; ENSMUST00000098896; ENSMUSP00000096495; ENSMUSG00000074442.
DR Ensembl; ENSMUST00000098899; ENSMUSP00000096498; ENSMUSG00000074446.
DR GeneID; 13226; -.
DR GeneID; 497114; -.
DR KEGG; mmu:13226; -.
DR KEGG; mmu:497114; -.
DR UCSC; uc009lbk.2; mouse.
DR CTD; 13226; -.
DR CTD; 497114; -.
DR MGI; MGI:3630381; Defa23.
DR VEuPathDB; HostDB:ENSMUSG00000074442; -.
DR VEuPathDB; HostDB:ENSMUSG00000074446; -.
DR eggNOG; ENOG502T2EX; Eukaryota.
DR GeneTree; ENSGT00940000153268; -.
DR HOGENOM; CLU_160803_1_0_1; -.
DR InParanoid; Q5G866; -.
DR OMA; QDMDISF; -.
DR OrthoDB; 1610714at2759; -.
DR PhylomeDB; Q5G866; -.
DR TreeFam; TF338414; -.
DR Reactome; R-MMU-1461973; Defensins.
DR Reactome; R-MMU-1462054; Alpha-defensins.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 13226; 5 hits in 33 CRISPR screens.
DR BioGRID-ORCS; 497114; 5 hits in 14 CRISPR screens.
DR PRO; PR:Q5G866; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q5G866; protein.
DR Bgee; ENSMUSG00000074442; Expressed in colon and 12 other tissues.
DR GO; GO:0042582; C:azurophil granule; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..58
FT /evidence="ECO:0000250"
FT /id="PRO_0000300072"
FT PEPTIDE 59..92
FT /note="Alpha-defensin 23"
FT /id="PRO_0000300073"
FT REGION 24..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 64..92
FT /evidence="ECO:0000250"
FT DISULFID 66..81
FT /evidence="ECO:0000250"
FT DISULFID 71..91
FT /evidence="ECO:0000250"
FT CONFLICT 11
FT /note="I -> V (in Ref. 2; AAI25551/AAI25549)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="K -> E (in Ref. 2; AAI25551/AAI25549)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="I -> M (in Ref. 2; AAI25551/AAI25549)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 93 AA; 10510 MW; 3B3D87557D869A49 CRC64;
MKTLVLLSAL ILLAFQVQAD PIQNTDEETK TEEQPGKEDQ AVSVSFGDPE GSSLQEESLR
DLVCYCRTRG CKRRERMNGT CRKGHLIYTL CCR
