ID   DFA25_MOUSE             Reviewed;          92 AA.
AC   Q5G864;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Alpha-defensin 25;
DE   AltName: Full=Defensin-related cryptdin-25;
DE   Flags: Precursor;
GN   Name=Defa25; Synonyms=Defcr25;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15494476; DOI=10.1152/physiolgenomics.00150.2004;
RA   Patil A., Hughes A.L., Zhang G.;
RT   "Rapid evolution and diversification of mammalian alpha-defensins as
RT   revealed by comparative analysis of rodent and primate genes.";
RL   Physiol. Genomics 20:1-11(2004).
CC   -!- FUNCTION: May have microbicidal activities. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   EMBL; AY746430; AAW78339.1; -; mRNA.
DR   CCDS; CCDS52502.1; -.
DR   RefSeq; NP_031875.1; NM_007849.1.
DR   AlphaFoldDB; Q5G864; -.
DR   SMR; Q5G864; -.
DR   STRING; 10090.ENSMUSP00000093075; -.
DR   PaxDb; Q5G864; -.
DR   PRIDE; Q5G864; -.
DR   Ensembl; ENSMUST00000095425; ENSMUSP00000093075; ENSMUSG00000094687.
DR   GeneID; 13236; -.
DR   KEGG; mmu:13236; -.
DR   UCSC; uc012gaq.1; mouse.
DR   CTD; 13236; -.
DR   MGI; MGI:3630385; Defa25.
DR   VEuPathDB; HostDB:ENSMUSG00000094687; -.
DR   GeneTree; ENSGT00940000153268; -.
DR   HOGENOM; CLU_160803_1_0_1; -.
DR   InParanoid; Q5G864; -.
DR   OrthoDB; 1610714at2759; -.
DR   PhylomeDB; Q5G864; -.
DR   TreeFam; TF338414; -.
DR   Reactome; R-MMU-1461973; Defensins.
DR   Reactome; R-MMU-1462054; Alpha-defensins.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 13236; 5 hits in 38 CRISPR screens.
DR   PRO; PR:Q5G864; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q5G864; protein.
DR   Bgee; ENSMUSG00000094687; Expressed in ileum and 1 other tissue.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR   GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR002366; Alpha-defensin_propep.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   PANTHER; PTHR11876; PTHR11876; 1.
DR   Pfam; PF00323; Defensin_1; 1.
DR   Pfam; PF00879; Defensin_propep; 1.
DR   PIRSF; PIRSF001875; Alpha-defensin; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..57
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000300076"
FT   PEPTIDE         58..92
FT                   /note="Alpha-defensin 25"
FT                   /id="PRO_0000300077"
FT   REGION          24..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        63..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10457 MW;  51CAC70C44025D6A CRC64;
     MKTLVLLSAL ALLAFQVQAD PIQNRDEESK IDEQPGKEDQ AVSVSFGDPE GSSLQEECED
     LICYCRTRGC KRRERLNGTC RKGHLMYMLW CC