DFA26_MOUSE
ID DFA26_MOUSE Reviewed; 93 AA.
AC Q3L180;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Alpha-defensin 26;
DE AltName: Full=Defensin-related cryptdin-26;
DE Flags: Precursor;
GN Name=Defa26; Synonyms=Defcr26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15494476; DOI=10.1152/physiolgenomics.00150.2004;
RA Patil A., Hughes A.L., Zhang G.;
RT "Rapid evolution and diversification of mammalian alpha-defensins as
RT revealed by comparative analysis of rodent and primate genes.";
RL Physiol. Genomics 20:1-11(2004).
CC -!- FUNCTION: May have microbicidal activities. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; AY766470; AAX10126.1; -; mRNA.
DR CCDS; CCDS40278.1; -.
DR RefSeq; NP_001073402.1; NM_001079933.2.
DR AlphaFoldDB; Q3L180; -.
DR SMR; Q3L180; -.
DR BioGRID; 552851; 3.
DR STRING; 10090.ENSMUSP00000073950; -.
DR PaxDb; Q3L180; -.
DR PRIDE; Q3L180; -.
DR DNASU; 626708; -.
DR Ensembl; ENSMUST00000074343; ENSMUSP00000073950; ENSMUSG00000060070.
DR GeneID; 626708; -.
DR KEGG; mmu:626708; -.
DR UCSC; uc009lbs.2; mouse.
DR CTD; 626708; -.
DR MGI; MGI:3630390; Defa26.
DR VEuPathDB; HostDB:ENSMUSG00000060070; -.
DR eggNOG; ENOG502T2EX; Eukaryota.
DR GeneTree; ENSGT00940000153268; -.
DR HOGENOM; CLU_160803_1_0_1; -.
DR InParanoid; Q3L180; -.
DR OrthoDB; 1610714at2759; -.
DR PhylomeDB; Q3L180; -.
DR TreeFam; TF338414; -.
DR Reactome; R-MMU-1461973; Defensins.
DR Reactome; R-MMU-1462054; Alpha-defensins.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 626708; 7 hits in 37 CRISPR screens.
DR PRO; PR:Q3L180; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3L180; protein.
DR Bgee; ENSMUSG00000060070; Expressed in ileum and 7 other tissues.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0051873; P:killing by host of symbiont cells; ISO:MGI.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:1905710; P:positive regulation of membrane permeability; ISO:MGI.
DR GO; GO:0051289; P:protein homotetramerization; ISO:MGI.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..58
FT /evidence="ECO:0000250"
FT /id="PRO_0000300078"
FT PEPTIDE 59..93
FT /note="Alpha-defensin 26"
FT /id="PRO_0000300079"
FT REGION 24..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 64..92
FT /evidence="ECO:0000250"
FT DISULFID 66..81
FT /evidence="ECO:0000250"
FT DISULFID 71..91
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10514 MW; 59A426280D4618F7 CRC64;
MKTLVLLSAL FLLAFQVQAD PIQNTDEETN TEVQPQEEDQ AVSVSFGNPE GSDLQEESLR
DLGCYCRKRG CTRRERINGT CRKGHLMYTL CCL
