DFA29_MOUSE
ID DFA29_MOUSE Reviewed; 116 AA.
AC P17533; Q9QVW7;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Alpha-defensin 29 {ECO:0000305};
DE AltName: Full=Alpha-defensin-related sequence 1 {ECO:0000312|MGI:MGI:94881};
DE AltName: Full=CRS1C {ECO:0000312|MGI:MGI:94881};
DE AltName: Full=Cryptdin-related protein 1C {ECO:0000303|PubMed:2351676};
DE AltName: Full=Defensin-related cryptdin-related sequence 1;
DE Flags: Precursor;
GN Name=Defa29 {ECO:0000312|MGI:MGI:94881};
GN Synonyms=Defa-rs1 {ECO:0000312|MGI:MGI:94881}, Defcr-rs1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=CD-1; TISSUE=Small intestine;
RX PubMed=2351676; DOI=10.1016/s0021-9258(19)38746-0;
RA Ouellette A.J., Lauldi J.C.;
RT "A novel mouse gene family coding for cationic, cysteine-rich peptides.
RT Regulation in small intestine and cells of myeloid origin.";
RL J. Biol. Chem. 265:9831-9837(1990).
RN [2]
RP ERRATUM OF PUBMED:2351676, AND SEQUENCE REVISION.
RX PubMed=8034619; DOI=10.1016/s0021-9258(17)32367-0;
RA Ouellette A.J., Lauldi J.C.;
RL J. Biol. Chem. 269:18702-18702(1994).
CC -!- FUNCTION: Apparent precursor of a secreted, cationic, proline- and
CC cysteine-rich peptide that contains Cys-Pro-Xaa repeats
CC (PubMed:2351676). Unlike cryptdin, the proposed mature peptide region
CC lacks the structural motif characteristic of defensins
CC (PubMed:2351676). {ECO:0000269|PubMed:2351676}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Small bowel. {ECO:0000269|PubMed:2351676}.
CC -!- DEVELOPMENTAL STAGE: Accumulates to high levels in intestinal crypt
CC epithelium from 14 days of age to 40 days of age.
CC {ECO:0000269|PubMed:2351676}.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; M33226; AAA18201.1; -; mRNA.
DR CCDS; CCDS40271.1; -.
DR PIR; B53701; B53701.
DR AlphaFoldDB; P17533; -.
DR STRING; 10090.ENSMUSP00000096489; -.
DR MaxQB; P17533; -.
DR PaxDb; P17533; -.
DR PeptideAtlas; P17533; -.
DR PRIDE; P17533; -.
DR ProteomicsDB; 277316; -.
DR MGI; MGI:94881; Defa29.
DR eggNOG; ENOG502TF4X; Eukaryota.
DR InParanoid; P17533; -.
DR PhylomeDB; P17533; -.
DR Reactome; R-MMU-1461973; Defensins.
DR Reactome; R-MMU-1462054; Alpha-defensins.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR PRO; PR:P17533; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P17533; protein.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Defensin; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..60
FT /evidence="ECO:0000255"
FT /id="PRO_0000006849"
FT CHAIN 61..116
FT /note="Alpha-defensin 29"
FT /id="PRO_0000006850"
FT REPEAT 65..67
FT /note="1-1"
FT REPEAT 68..70
FT /note="1-2"
FT REPEAT 71..73
FT /note="2-1"
FT REPEAT 74..76
FT /note="2-2"
FT REPEAT 77..79
FT /note="2-3"
FT REPEAT 80..82
FT /note="3-1"
FT REPEAT 83..85
FT /note="3-2"
FT REPEAT 86..88
FT /note="3-3"
FT REPEAT 89..91
FT /note="3-4"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..70
FT /note="2 X 3 AA tandem repeats of C-R-X"
FT REGION 71..79
FT /note="3 X 3 AA tandem repeats of C-Q-X"
FT REGION 80..91
FT /note="4 X 3 AA tandem repeats of C-P-X"
SQ SEQUENCE 116 AA; 12941 MW; 2242F29804F83F45 CRC64;
MKTLVLLSAL VLPCFQVQAD PIQNTDEETK TEEQPEEEDQ AVSVSFGGTE GSALQDVAQR
RFPWCRKCRV CQKCQVCQKC PVCPTCPQCP KQPLCEERQN KTAITTQAPN TQHKGC
