ID   DFA6_NOSS1              Reviewed;         570 AA.
AC   Q8YQE2;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Putative diflavin flavoprotein A 6;
DE            EC=1.-.-.-;
GN   Name=dfa6; OrderedLocusNames=all3891;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Mediates electron transfer from NADH to oxygen, reducing it
CC       to water. This modular protein has 3 redox cofactors, in other
CC       organisms the same activity requires 2 or 3 proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC       Note=Binds 2 iron ions per subunit.;
CC   -!- MISCELLANEOUS: By homology with NorV in E.coli, may be involved in
CC       nitric oxide detoxification. {ECO:0000250}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the zinc metallo-
CC       hydrolase group 3 family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the flavodoxin
CC       reductase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000019; BAB75590.1; -; Genomic_DNA.
DR   PIR; AD2292; AD2292.
DR   RefSeq; WP_010998032.1; NZ_RSCN01000011.1.
DR   AlphaFoldDB; Q8YQE2; -.
DR   SMR; Q8YQE2; -.
DR   STRING; 103690.17133025; -.
DR   EnsemblBacteria; BAB75590; BAB75590; BAB75590.
DR   KEGG; ana:all3891; -.
DR   eggNOG; COG0426; Bacteria.
DR   eggNOG; COG1853; Bacteria.
DR   OMA; HVKNNIH; -.
DR   OrthoDB; 1149616at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016646; F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR   Gene3D; 2.30.110.10; -; 1.
DR   Gene3D; 3.40.50.360; -; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR002563; Flavin_Rdtase-like_dom.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR001226; Flavodoxin_CS.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   Pfam; PF01613; Flavin_Reduct; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   SMART; SM00903; Flavin_Reduct; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   PROSITE; PS00201; FLAVODOXIN; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   3: Inferred from homology;
KW   Electron transport; Oxidoreductase; Reference proteome; Transport.
FT   CHAIN           1..570
FT                   /note="Putative diflavin flavoprotein A 6"
FT                   /id="PRO_0000216798"
FT   DOMAIN          260..402
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00088"
FT   REGION          38..231
FT                   /note="Zinc metallo-hydrolase"
FT   REGION          421..570
FT                   /note="Flavodoxin-reductase-like"
SQ   SEQUENCE   570 AA;  62259 MW;  2F942F975F9B013E CRC64;
     MSQTKPRDVQ VLPIGTNTTV LRSRSWTRLR FEIEYALAKG TTANSYLIQG DKLALIDPPG
     ETFTQIYLDA LQKRLDVTEI NYVILGHINP NRAATLKALL EIAPQITFVC SNPGAINLRG
     VLENPDLPML IMRGEETLDL GKGHNLQFIP TPNPRYADEL CTYDPQTEIL YTDKLFGAHI
     CGDQVFDEGW ATINEDRRYY YDCLMAPHAR QVETALDKLA DFPTRLYATG HGPLVRYGLI
     ELTHAYREWS QQQTSADLTV ALIYASAYGN TATLAQAIAR GITKAGVAVE SINCEFADPE
     EIRAAVEKSA GFVMGSPTLG GHAPTPVQTA LGIVLSTATN NKLAGVFGSF GWSGEAVDLI
     ESKLKDAGYR FGFDSIRVKF KPNEVTLQMC EEAGTDFAQA LKKARKVRTQ SVPATNVEQA
     VGRIVGSLCV VTAKQGEISS AMLASWVAQA SFNPPGLTIA VAKDRAVETL THTGNKFVLN
     VLKEGNHLGL MKHFLKPFGP AQDRFADVAT AEAENGSPVL QDALAYLECS VQNRMESGDH
     WLVYATVENG KVLNQDGVTA VHHRKSGNHY