DFB10_BOVIN
ID DFB10_BOVIN Reviewed; 62 AA.
AC P46168; Q5W5G8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 3.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Beta-defensin 10;
DE AltName: Full=BNBD-10;
DE AltName: Full=BNDB-10;
DE AltName: Full=Neutrophil beta-defensin 10;
DE Flags: Precursor;
GN Name=DEFB10; Synonyms=BNBD10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15520886; DOI=10.1007/s00335-004-2387-z;
RA Roosen S., Exner K., Paul S., Schroder J.M., Kalm E., Looft C.;
RT "Bovine beta-defensins: identification and characterization of novel bovine
RT beta-defensin genes and their expression in mammary gland tissue.";
RL Mamm. Genome 15:834-842(2004).
RN [2]
RP PROTEIN SEQUENCE OF 23-62, AND PYROGLUTAMATE FORMATION AT GLN-23.
RC STRAIN=Hereford; TISSUE=Neutrophil;
RX PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA Smith W., Henschen A.H., Cullor J.S.;
RT "Purification, primary structures, and antibacterial activities of beta-
RT defensins, a new family of antimicrobial peptides from bovine
RT neutrophils.";
RL J. Biol. Chem. 268:6641-6648(1993).
CC -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC S.aureus 502A.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ567990; CAD99422.1; -; Genomic_DNA.
DR EMBL; AJ567991; CAD99422.1; JOINED; Genomic_DNA.
DR PIR; A47753; A47753.
DR RefSeq; NP_001108556.1; NM_001115084.1.
DR AlphaFoldDB; P46168; -.
DR SMR; P46168; -.
DR STRING; 9913.ENSBTAP00000046539; -.
DR PaxDb; P46168; -.
DR PeptideAtlas; P46168; -.
DR PRIDE; P46168; -.
DR GeneID; 100141457; -.
DR KEGG; bta:100141457; -.
DR CTD; 246085; -.
DR InParanoid; P46168; -.
DR OrthoDB; 1584343at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR Pfam; PF00711; Defensin_beta; 1.
DR SMART; SM00048; DEFSN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:8454635"
FT PEPTIDE 23..62
FT /note="Beta-defensin 10"
FT /id="PRO_0000044725"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:8454635"
FT DISULFID 31..60
FT /evidence="ECO:0000250"
FT DISULFID 38..53
FT /evidence="ECO:0000250"
FT DISULFID 43..61
FT /evidence="ECO:0000250"
SQ SEQUENCE 62 AA; 6928 MW; 2D5EF8F9513FC3C5 CRC64;
MRLHHLLLLL LLVVLSSGSG FTQGVRSYLS CWGNRGICLL NRCPGRMRQI GTCLAPRVKC
CR
