ID   DFB10_MOUSE             Reviewed;          73 AA.
AC   Q8R2I8; A2A4E8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Beta-defensin 10;
DE            Short=BD-10;
DE            Short=mBD-10;
DE   AltName: Full=Defensin, beta 10;
DE   Flags: Precursor;
GN   Name=Defb10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6N; TISSUE=Testis;
RX   PubMed=12644567; DOI=10.1093/molbev/msg060;
RA   Morrison G.M., Semple C.A.M., Kilanowski F.M., Hill R.E., Dorin J.R.;
RT   "Signal sequence conservation and mature peptide divergence within
RT   subgroups of the murine beta-defensin gene family.";
RL   Mol. Biol. Evol. 20:460-470(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in both adult and neonate brain, and very
CC       weakly in kidneys, epididymis, and testis.
CC       {ECO:0000269|PubMed:12644567}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AJ437645; CAD26894.1; -; mRNA.
DR   EMBL; AL590619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS40285.1; -.
DR   RefSeq; NP_631971.1; NM_139225.1.
DR   AlphaFoldDB; Q8R2I8; -.
DR   SMR; Q8R2I8; -.
DR   STRING; 10090.ENSMUSP00000061533; -.
DR   PaxDb; Q8R2I8; -.
DR   PRIDE; Q8R2I8; -.
DR   DNASU; 246085; -.
DR   Ensembl; ENSMUST00000054162; ENSMUSP00000061533; ENSMUSG00000044743.
DR   GeneID; 246085; -.
DR   KEGG; mmu:246085; -.
DR   UCSC; uc009lcb.1; mouse.
DR   CTD; 246085; -.
DR   MGI; MGI:2179205; Defb10.
DR   VEuPathDB; HostDB:ENSMUSG00000044743; -.
DR   GeneTree; ENSGT00940000165558; -.
DR   HOGENOM; CLU_189296_1_0_1; -.
DR   InParanoid; Q8R2I8; -.
DR   OMA; CHYNICP; -.
DR   OrthoDB; 1584343at2759; -.
DR   PhylomeDB; Q8R2I8; -.
DR   BioGRID-ORCS; 246085; 1 hit in 53 CRISPR screens.
DR   PRO; PR:Q8R2I8; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q8R2I8; protein.
DR   Bgee; ENSMUSG00000044743; Expressed in prostate gland ventral lobe and 21 other tissues.
DR   Genevisible; Q8R2I8; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..73
FT                   /note="Beta-defensin 10"
FT                   /id="PRO_0000006938"
FT   DISULFID        37..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..67
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  8393 MW;  7A6EBFB4C96FF8E7 CRC64;
     MRTLCSLLLI CCLLFSYTTP AVGDLKHLIL KAQLTRCYKF GGFCHYNICP GNSRFMSNCH
     PENLRCCKNI KQF