ID   DFB11_BOVIN             Reviewed;          60 AA.
AC   P46169; Q5W5G7;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Beta-defensin 11;
DE   AltName: Full=BNBD-11;
DE   AltName: Full=BNDB-11;
DE   AltName: Full=Neutrophil beta-defensin 11;
DE   Flags: Precursor;
GN   Name=DEFB11; Synonyms=BNBD11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15520886; DOI=10.1007/s00335-004-2387-z;
RA   Roosen S., Exner K., Paul S., Schroder J.M., Kalm E., Looft C.;
RT   "Bovine beta-defensins: identification and characterization of novel bovine
RT   beta-defensin genes and their expression in mammary gland tissue.";
RL   Mamm. Genome 15:834-842(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 23-60.
RC   STRAIN=Hereford; TISSUE=Neutrophil;
RX   PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA   Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA   Smith W., Henschen A.H., Cullor J.S.;
RT   "Purification, primary structures, and antibacterial activities of beta-
RT   defensins, a new family of antimicrobial peptides from bovine
RT   neutrophils.";
RL   J. Biol. Chem. 268:6641-6648(1993).
CC   -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC       S.aureus 502A.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AJ567992; CAD99423.1; -; Genomic_DNA.
DR   EMBL; AJ567993; CAD99423.1; JOINED; Genomic_DNA.
DR   PIR; B47753; B47753.
DR   AlphaFoldDB; P46169; -.
DR   SMR; P46169; -.
DR   PRIDE; P46169; -.
DR   Ensembl; ENSBTAT00000078961; ENSBTAP00000070487; ENSBTAG00000050630.
DR   VEuPathDB; HostDB:ENSBTAG00000050630; -.
DR   GeneTree; ENSGT00940000160995; -.
DR   InParanoid; P46169; -.
DR   OMA; IRSKGIC; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000050630; Expressed in thymus and 71 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:8454635"
FT   PEPTIDE         23..60
FT                   /note="Beta-defensin 11"
FT                   /id="PRO_0000044726"
FT   DISULFID        27..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..57
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   60 AA;  6507 MW;  25D05BF218C166DE CRC64;
     MRLHHLLLAL LFLVLSAGSG ISGPLSCRRN GGVCIPIRCP GPMRQIGTCF GRPVKCCRSW