DFB11_MOUSE
ID DFB11_MOUSE Reviewed; 77 AA.
AC Q8R2I7; Q499L3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Beta-defensin 11;
DE Short=BD-11;
DE Short=mBD-11;
DE AltName: Full=Defensin, beta 11;
DE Flags: Precursor;
GN Name=Defb11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6N; TISSUE=Testis;
RX PubMed=12644567; DOI=10.1093/molbev/msg060;
RA Morrison G.M., Semple C.A.M., Kilanowski F.M., Hill R.E., Dorin J.R.;
RT "Signal sequence conservation and mature peptide divergence within
RT subgroups of the murine beta-defensin gene family.";
RL Mol. Biol. Evol. 20:460-470(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in both adult and neonate brain, and very
CC weakly in kidneys, epididymis, and testis.
CC {ECO:0000269|PubMed:12644567}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ437646; CAD26895.1; -; mRNA.
DR EMBL; AL590619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC099849; AAH99849.1; -; mRNA.
DR CCDS; CCDS52515.1; -.
DR RefSeq; NP_631967.1; NM_139221.2.
DR AlphaFoldDB; Q8R2I7; -.
DR SMR; Q8R2I7; -.
DR STRING; 10090.ENSMUSP00000053932; -.
DR PaxDb; Q8R2I7; -.
DR PRIDE; Q8R2I7; -.
DR DNASU; 246081; -.
DR Ensembl; ENSMUST00000051965; ENSMUSP00000053932; ENSMUSG00000045337.
DR GeneID; 246081; -.
DR KEGG; mmu:246081; -.
DR UCSC; uc009lcd.2; mouse.
DR CTD; 246081; -.
DR MGI; MGI:2179197; Defb11.
DR VEuPathDB; HostDB:ENSMUSG00000045337; -.
DR GeneTree; ENSGT00940000165558; -.
DR HOGENOM; CLU_189296_1_0_1; -.
DR InParanoid; Q8R2I7; -.
DR OMA; CCINMKE; -.
DR OrthoDB; 1584343at2759; -.
DR PhylomeDB; Q8R2I7; -.
DR BioGRID-ORCS; 246081; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8R2I7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R2I7; protein.
DR Bgee; ENSMUSG00000045337; Expressed in choroid plexus epithelium and 48 other tissues.
DR Genevisible; Q8R2I7; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..77
FT /note="Beta-defensin 11"
FT /id="PRO_0000006939"
FT DISULFID 37..66
FT /evidence="ECO:0000250"
FT DISULFID 44..59
FT /evidence="ECO:0000250"
FT DISULFID 49..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 77 AA; 8666 MW; 055F87DA75A9897C CRC64;
MRTLCSLLLI CCLLFSYTTP AVGDLKHLIL KAQLARCYKF GGFCYNSMCP PHTKFIGNCH
PDHLHCCINM KELEGST
