ID   DFB11_RAT               Reviewed;          69 AA.
AC   Q32ZI0;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Beta-defensin 11;
DE            Short=BD-11;
DE   AltName: Full=Defensin, beta 11;
DE   Flags: Precursor;
GN   Name=Defb11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621343; AAT51882.1; -; mRNA.
DR   RefSeq; NP_001032594.1; NM_001037505.1.
DR   AlphaFoldDB; Q32ZI0; -.
DR   STRING; 10116.ENSRNOP00000054871; -.
DR   TCDB; 1.C.85.1.7; the pore-forming Beta-defensin (Beta-defensin) family.
DR   PaxDb; Q32ZI0; -.
DR   Ensembl; ENSRNOT00000058063; ENSRNOP00000054871; ENSRNOG00000038151.
DR   GeneID; 641630; -.
DR   KEGG; rno:641630; -.
DR   UCSC; RGD:1564032; rat.
DR   CTD; 246081; -.
DR   RGD; 1564032; Defb11.
DR   GeneTree; ENSGT00940000165558; -.
DR   HOGENOM; CLU_189296_1_0_1; -.
DR   InParanoid; Q32ZI0; -.
DR   OMA; VSEMERC; -.
DR   PRO; PR:Q32ZI0; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000038151; Expressed in kidney and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..69
FT                   /note="Beta-defensin 11"
FT                   /id="PRO_0000352696"
FT   DISULFID        35..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..65
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   69 AA;  8078 MW;  C69F78C1385E3BD5 CRC64;
     MRTLCSLLLI GCLLFSYDTP VVGFLRRSVS GFQECHSKGG YCYRYYCPRP HRRLGSCYPY
     AANCCRRRR