DFB12_MOUSE
ID DFB12_MOUSE Reviewed; 78 AA.
AC Q8K4N3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Beta-defensin 12;
DE Short=BD-12;
DE Short=mBD-12;
DE AltName: Full=Defensin, beta 12;
DE Flags: Precursor;
GN Name=Defb12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epididymis;
RX PubMed=12193721; DOI=10.4049/jimmunol.169.5.2516;
RA Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T.,
RA Kurihara H., Ouchi Y.;
RT "Identification of multiple novel epididymis-specific beta-defensin
RT isoforms in humans and mice.";
RL J. Immunol. 169:2516-2523(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Only expressed in epididymis (caput, corpus and
CC cauda). {ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC10632.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC25621.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB089182; BAC10632.1; ALT_INIT; mRNA.
DR EMBL; AK020311; BAC25621.1; ALT_INIT; mRNA.
DR CCDS; CCDS52496.1; -.
DR RefSeq; NP_690015.1; NM_152802.3.
DR AlphaFoldDB; Q8K4N3; -.
DR STRING; 10090.ENSMUSP00000060899; -.
DR PaxDb; Q8K4N3; -.
DR PRIDE; Q8K4N3; -.
DR DNASU; 77674; -.
DR Ensembl; ENSMUST00000062113; ENSMUSP00000060899; ENSMUSG00000043787.
DR GeneID; 77674; -.
DR KEGG; mmu:77674; -.
DR UCSC; uc009lac.1; mouse.
DR CTD; 77674; -.
DR MGI; MGI:1924924; Defb12.
DR eggNOG; ENOG502TE24; Eukaryota.
DR GeneTree; ENSGT00390000002317; -.
DR InParanoid; Q8K4N3; -.
DR OrthoDB; 1579011at2759; -.
DR PhylomeDB; Q8K4N3; -.
DR BioGRID-ORCS; 77674; 0 hits in 69 CRISPR screens.
DR PRO; PR:Q8K4N3; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8K4N3; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..78
FT /note="Beta-defensin 12"
FT /id="PRO_0000006940"
FT DISULFID 46..73
FT /evidence="ECO:0000250"
FT DISULFID 53..67
FT /evidence="ECO:0000250"
FT DISULFID 57..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 78 AA; 8872 MW; BCA12AEBDA423989 CRC64;
MALSREVFYF GFALFFIVVE LPSGSWAGLE YSQSFPGGEI AVCETCRLGR GKCRRTCIES
EKIAGWCKLN FFCCRERI
