ID   DFB12_RAT               Reviewed;          78 AA.
AC   Q32ZH9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Beta-defensin 12;
DE            Short=BD-12;
DE   AltName: Full=Defensin, beta 12;
DE   Flags: Precursor;
GN   Name=Defb12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621344; AAT51883.1; -; mRNA.
DR   RefSeq; NP_001032603.1; NM_001037514.1.
DR   RefSeq; XP_008771555.1; XM_008773333.1.
DR   AlphaFoldDB; Q32ZH9; -.
DR   SMR; Q32ZH9; -.
DR   STRING; 10116.ENSRNOP00000045210; -.
DR   PaxDb; Q32ZH9; -.
DR   Ensembl; ENSRNOT00000044094; ENSRNOP00000045210; ENSRNOG00000038155.
DR   GeneID; 641643; -.
DR   KEGG; rno:641643; -.
DR   UCSC; RGD:1564879; rat.
DR   CTD; 77674; -.
DR   RGD; 1564879; Defb12.
DR   eggNOG; ENOG502TE24; Eukaryota.
DR   GeneTree; ENSGT00390000002317; -.
DR   HOGENOM; CLU_197691_0_0_1; -.
DR   InParanoid; Q32ZH9; -.
DR   OMA; CQAGLEF; -.
DR   OrthoDB; 1579011at2759; -.
DR   PhylomeDB; Q32ZH9; -.
DR   PRO; PR:Q32ZH9; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000038155; Expressed in kidney and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..78
FT                   /note="Beta-defensin 12"
FT                   /id="PRO_0000352697"
FT   DISULFID        46..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8730 MW;  2560AC8EFE6C6E63 CRC64;
     MALSRGTFYF GLALFFIVVE LPSGSWAGLE YSQSFPGGEF AVCETCRLGR GKCRRTCLDS
     EKIAGKCKLN FFCCRERI