ADA1D_RAT
ID ADA1D_RAT Reviewed; 561 AA.
AC P23944; Q71UM4;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Alpha-1D adrenergic receptor;
DE AltName: Full=Alpha-1A adrenergic receptor;
DE AltName: Full=Alpha-1D adrenoreceptor;
DE Short=Alpha-1D adrenoceptor;
DE AltName: Full=RA42;
GN Name=Adra1d; Synonyms=Adra1a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley; TISSUE=Brain cortex;
RX PubMed=1706716; DOI=10.1016/s0021-9258(18)38126-2;
RA Lomasney J.W., Cotecchia S., Lorenz W., Leung W.-Y., Schwinn D.A.,
RA Yang-Feng T.L., Brownstein M., Lefkowitz R.J., Caron M.G.;
RT "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic
RT receptor. The gene for which is located on human chromosome 5.";
RL J. Biol. Chem. 266:6365-6369(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hippocampus;
RX PubMed=1661838;
RA Perez D.M., Piascik M.T., Graham R.M.;
RT "Solution-phase library screening for the identification of rare clones:
RT isolation of an alpha 1D-adrenergic receptor cDNA.";
RL Mol. Pharmacol. 40:876-883(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7815325;
RA Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H.,
RA Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J.,
RA Peter B., Bailey D.S.;
RT "Cloning and pharmacological characterization of human alpha-1 adrenergic
RT receptors: sequence corrections and direct comparison with other species
RT homologues.";
RL J. Pharmacol. Exp. Ther. 272:134-142(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-62.
RX PubMed=10570042; DOI=10.1124/mol.56.6.1152;
RA Xin X., Yang N., Faber J.E.;
RT "Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic receptor
RT gene expression in vascular smooth muscle cells by inducing AP-2-like
RT protein binding to alpha1D proximal promoter region.";
RL Mol. Pharmacol. 56:1152-1161(1999).
CC -!- FUNCTION: This alpha-adrenergic receptor mediates its effect through
CC the influx of extracellular calcium.
CC -!- SUBUNIT: Interacts with FLNA (via filamin repeat 21); increases PKA-
CC mediated phosphorylation of FLNA. {ECO:0000250|UniProtKB:P25100}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Vas deferens, hippocampus, cerebral cortex, aorta,
CC brain stem, heart and spleen.
CC -!- PTM: Palmitoylated. Palmitoylation by ZDHHC21 may increase the
CC expression of the receptor and regulate downstream signaling.
CC {ECO:0000250|UniProtKB:P97714}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Adrenergic receptor subfamily. ADRA1D sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA63477.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M60654; AAA63477.1; ALT_FRAME; mRNA.
DR EMBL; L31771; AAB59704.1; -; mRNA.
DR EMBL; AF071014; AAC25396.1; -; Genomic_DNA.
DR PIR; A38731; A38731.
DR RefSeq; NP_077809.1; NM_024483.1.
DR AlphaFoldDB; P23944; -.
DR SMR; P23944; -.
DR STRING; 10116.ENSRNOP00000028877; -.
DR BindingDB; P23944; -.
DR ChEMBL; CHEMBL326; -.
DR DrugCentral; P23944; -.
DR GuidetoPHARMACOLOGY; 24; -.
DR GlyGen; P23944; 2 sites.
DR PhosphoSitePlus; P23944; -.
DR PaxDb; P23944; -.
DR GeneID; 29413; -.
DR KEGG; rno:29413; -.
DR UCSC; RGD:62064; rat.
DR CTD; 146; -.
DR RGD; 62064; Adra1d.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P23944; -.
DR OrthoDB; 1095345at2759; -.
DR PhylomeDB; P23944; -.
DR Reactome; R-RNO-390696; Adrenoceptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-416482; G alpha (12/13) signalling events.
DR PRO; PR:P23944; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005829; C:cytosol; IDA:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004937; F:alpha1-adrenergic receptor activity; IDA:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007568; P:aging; IDA:RGD.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0060073; P:micturition; IMP:RGD.
DR GO; GO:0010259; P:multicellular organism aging; ISO:RGD.
DR GO; GO:0001986; P:negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure; ISO:RGD.
DR GO; GO:0150099; P:neuron-glial cell signaling; ISO:RGD.
DR GO; GO:0001994; P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; ISO:RGD.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0001996; P:positive regulation of heart rate by epinephrine-norepinephrine; IBA:GO_Central.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
DR GO; GO:0008217; P:regulation of blood pressure; ISO:RGD.
DR InterPro; IPR002233; ADR_fam.
DR InterPro; IPR000363; ADRA1D_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248:SF14; PTHR24248:SF14; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01103; ADRENERGICR.
DR PRINTS; PR00240; ADRENRGCA1DR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..561
FT /note="Alpha-1D adrenergic receptor"
FT /id="PRO_0000069077"
FT TOPO_DOM 1..90
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 91..115
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 116..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 128..153
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 154..163
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 164..186
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 187..207
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 208..232
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 233..245
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 246..269
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 270..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 343..367
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 368..374
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 375..399
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 400..561
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 10..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 413
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 561 AA; 59354 MW; B6537DCAD4F7BE27 CRC64;
MTFRDILSVT FEGPRSSSST GGSGAGGGAG TVGPEGGAVG GVPGATGGGA VVGTGSGEDN
QSSTGEPGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF ILTAVAGNLL VILSVACNRH
LQTVTNYFIV NLAVADLLLS AAVLPFSATM EVLGFWAFGR TFCDVWAAVD VLCCTASILS
LCTISVDRYV GVRHSLKYPA IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC
GITEEVGYAI FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI
HCRGAATSAK GYPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV FVLCWFPFFF
VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS REFKRAFLRL LRCQCRRRRR
RLWAVYGHHW RASTGDARSD CAPSPRIAPP GAPLALTAHP GAGSADTPET QDSVSSSRKP
ASALREWRLL GPLQRPTTQL RAKVSSLSHK IRSGARRAET ACALRSEVEA VSLNVPQDGA
EAVICQAYEP GDYSNLRETD I
