DFB13_BOVIN
ID DFB13_BOVIN Reviewed; 42 AA.
AC P46171;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Beta-defensin 13;
DE AltName: Full=BNBD-13;
DE AltName: Full=BNDB-13;
GN Name=DEFB13;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP PROTEIN SEQUENCE, AND DISULFIDE BONDS.
RC TISSUE=Neutrophil;
RX PubMed=8454635; DOI=10.1016/s0021-9258(18)53298-1;
RA Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J.,
RA Smith W., Henschen A.H., Cullor J.S.;
RT "Purification, primary structures, and antibacterial activities of beta-
RT defensins, a new family of antimicrobial peptides from bovine
RT neutrophils.";
RL J. Biol. Chem. 268:6641-6648(1993).
CC -!- FUNCTION: Has bactericidal activity. Active against E.coli ML35 and
CC S.aureus 502A.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Neutrophilic granules.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; D47753; D47753.
DR AlphaFoldDB; P46171; -.
DR SMR; P46171; -.
DR InParanoid; P46171; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR Pfam; PF00711; Defensin_beta; 1.
DR SMART; SM00048; DEFSN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW Disulfide bond; Reference proteome; Secreted.
FT CHAIN 1..42
FT /note="Beta-defensin 13"
FT /id="PRO_0000064335"
FT DISULFID 9..38
FT /evidence="ECO:0000269|PubMed:8454635"
FT DISULFID 16..31
FT /evidence="ECO:0000269|PubMed:8454635"
FT DISULFID 21..39
FT /evidence="ECO:0000269|PubMed:8454635"
SQ SEQUENCE 42 AA; 4450 MW; BEA5C5806A04910B CRC64;
SGISGPLSCG RNGGVCIPIR CPVPMRQIGT CFGRPVKCCR SW