DFB13_MOUSE
ID DFB13_MOUSE Reviewed; 64 AA.
AC Q8R2I4; A2A4E3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Beta-defensin 13;
DE Short=BD-13;
DE Short=mBD-13;
DE AltName: Full=Defensin, beta 13;
DE Flags: Precursor;
GN Name=Defb13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6N; TISSUE=Testis;
RX PubMed=12644567; DOI=10.1093/molbev/msg060;
RA Morrison G.M., Semple C.A.M., Kilanowski F.M., Hill R.E., Dorin J.R.;
RT "Signal sequence conservation and mature peptide divergence within
RT subgroups of the murine beta-defensin gene family.";
RL Mol. Biol. Evol. 20:460-470(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and to a lesser extent in
CC epididymis (caput, corpus and cauda). Also weakly expressed in kidneys.
CC {ECO:0000269|PubMed:12644567, ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ575427; CAE01400.1; -; mRNA.
DR EMBL; AJ437649; CAD26898.1; -; mRNA.
DR EMBL; AL590619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS40290.1; -.
DR RefSeq; NP_631969.1; NM_139223.3.
DR AlphaFoldDB; Q8R2I4; -.
DR STRING; 10090.ENSMUSP00000060997; -.
DR PaxDb; Q8R2I4; -.
DR PRIDE; Q8R2I4; -.
DR DNASU; 246083; -.
DR Ensembl; ENSMUST00000060587; ENSMUSP00000060997; ENSMUSG00000044222.
DR GeneID; 246083; -.
DR KEGG; mmu:246083; -.
DR UCSC; uc009lcg.1; mouse.
DR CTD; 246083; -.
DR MGI; MGI:2179203; Defb13.
DR VEuPathDB; HostDB:ENSMUSG00000044222; -.
DR eggNOG; ENOG502TF47; Eukaryota.
DR GeneTree; ENSGT00390000013953; -.
DR HOGENOM; CLU_2757177_0_0_1; -.
DR InParanoid; Q8R2I4; -.
DR OMA; RRFLCKK; -.
DR OrthoDB; 1617545at2759; -.
DR PhylomeDB; Q8R2I4; -.
DR BioGRID-ORCS; 246083; 2 hits in 68 CRISPR screens.
DR PRO; PR:Q8R2I4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R2I4; protein.
DR Bgee; ENSMUSG00000044222; Expressed in animal zygote and 3 other tissues.
DR Genevisible; Q8R2I4; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..64
FT /note="Beta-defensin 13"
FT /id="PRO_0000006941"
FT DISULFID 30..57
FT /evidence="ECO:0000250"
FT DISULFID 37..51
FT /evidence="ECO:0000250"
FT DISULFID 41..58
FT /evidence="ECO:0000250"
SQ SEQUENCE 64 AA; 7520 MW; DE59FD61AB98AC8C CRC64;
MRIFSLIVAG LVLLIQLYPA WGTLYRRFLC KKMNGQCEAE CFTFEQKIGT CQANFLCCRK
RKEH
