ID   DFB13_RAT               Reviewed;          66 AA.
AC   Q32ZH8;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Beta-defensin 13;
DE            Short=BD-13;
DE   AltName: Full=Defensin, beta 13;
DE   Flags: Precursor;
GN   Name=Defb13;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621345; AAT51884.1; -; mRNA.
DR   RefSeq; NP_001032592.1; NM_001037503.1.
DR   AlphaFoldDB; Q32ZH8; -.
DR   STRING; 10116.ENSRNOP00000054879; -.
DR   PaxDb; Q32ZH8; -.
DR   Ensembl; ENSRNOT00000058071; ENSRNOP00000054879; ENSRNOG00000038157.
DR   GeneID; 641626; -.
DR   KEGG; rno:641626; -.
DR   UCSC; RGD:1559883; rat.
DR   CTD; 246083; -.
DR   RGD; 1559883; Defb13.
DR   eggNOG; ENOG502TF47; Eukaryota.
DR   GeneTree; ENSGT00390000013953; -.
DR   HOGENOM; CLU_2757177_0_0_1; -.
DR   InParanoid; Q32ZH8; -.
DR   OMA; RRFLCKK; -.
DR   OrthoDB; 1617545at2759; -.
DR   PhylomeDB; Q32ZH8; -.
DR   PRO; PR:Q32ZH8; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000038157; Expressed in kidney and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; ISO:RGD.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..66
FT                   /note="Beta-defensin 13"
FT                   /id="PRO_0000352698"
FT   DISULFID        30..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7539 MW;  A77FFE7E0A712D95 CRC64;
     MRIFSLIVAG LVLLIQLHPA KGTLYRRFLC KKMKGRCETA CLSFEKKIGT CRADLTPLCC
     KEKKKH