DFB14_MOUSE
ID DFB14_MOUSE Reviewed; 67 AA.
AC Q7TNV9; Q14BD1;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Beta-defensin 14;
DE Short=BD-14;
DE Short=mBD-14;
DE AltName: Full=Defensin, beta 14;
DE Flags: Precursor;
GN Name=Defb14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Maxwell A., Dorin J.R.;
RT "Amino acid residues subject to positive selection in murine b-defensin
RT antimicrobial peptides.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ578468; CAE17665.2; -; mRNA.
DR EMBL; BC116199; AAI16200.1; -; mRNA.
DR CCDS; CCDS40253.1; -.
DR RefSeq; NP_898847.1; NM_183026.2.
DR RefSeq; XP_006508855.1; XM_006508792.2.
DR RefSeq; XP_006508857.1; XM_006508794.3.
DR RefSeq; XP_006508858.1; XM_006508795.3.
DR RefSeq; XP_006508860.1; XM_006508797.3.
DR AlphaFoldDB; Q7TNV9; -.
DR SMR; Q7TNV9; -.
DR STRING; 10090.ENSMUSP00000062781; -.
DR TCDB; 1.C.85.1.4; the pore-forming Beta-defensin (Beta-defensin) family.
DR PaxDb; Q7TNV9; -.
DR PRIDE; Q7TNV9; -.
DR ProteomicsDB; 279347; -.
DR Ensembl; ENSMUST00000052601; ENSMUSP00000062781; ENSMUSG00000046354.
DR GeneID; 244332; -.
DR KEGG; mmu:244332; -.
DR UCSC; uc009lai.2; mouse.
DR CTD; 244332; -.
DR MGI; MGI:2675345; Defb14.
DR VEuPathDB; HostDB:ENSMUSG00000046354; -.
DR eggNOG; ENOG502TF5P; Eukaryota.
DR GeneTree; ENSGT00530000064280; -.
DR HOGENOM; CLU_189296_2_0_1; -.
DR InParanoid; Q7TNV9; -.
DR OMA; EQIGHCS; -.
DR OrthoDB; 1630404at2759; -.
DR PhylomeDB; Q7TNV9; -.
DR Reactome; R-MMU-1461957; Beta defensins.
DR Reactome; R-MMU-1461973; Defensins.
DR BioGRID-ORCS; 244332; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Defb14; mouse.
DR PRO; PR:Q7TNV9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q7TNV9; protein.
DR Bgee; ENSMUSG00000046354; Expressed in esophagus and 19 other tissues.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IDA:MGI.
DR GO; GO:0060326; P:cell chemotaxis; IDA:MGI.
DR GO; GO:0042742; P:defense response to bacterium; IDA:MGI.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..67
FT /note="Beta-defensin 14"
FT /id="PRO_0000006942"
FT DISULFID 33..62
FT /evidence="ECO:0000250"
FT DISULFID 40..55
FT /evidence="ECO:0000250"
FT DISULFID 45..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 67 AA; 7718 MW; EEFF0D93ADF17452 CRC64;
MRLHYLLFVF LILFLVPAPG DAFLPKTLRK FFCRIRGGRC AVLNCLGKEE QIGRCSNSGR
KCCRKKK
