ID   DFB14_RAT               Reviewed;          67 AA.
AC   Q32ZH7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Beta-defensin 14;
DE            Short=BD-14;
DE   AltName: Full=Defensin, beta 14;
DE   Flags: Precursor;
GN   Name=Defb14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY621346; AAT51885.1; -; mRNA.
DR   RefSeq; NP_001032593.1; NM_001037504.1.
DR   RefSeq; XP_006253434.1; XM_006253372.2.
DR   RefSeq; XP_017455730.1; XM_017600241.1.
DR   AlphaFoldDB; Q32ZH7; -.
DR   SMR; Q32ZH7; -.
DR   STRING; 10116.ENSRNOP00000048330; -.
DR   PaxDb; Q32ZH7; -.
DR   Ensembl; ENSRNOT00000048414; ENSRNOP00000048330; ENSRNOG00000032304.
DR   GeneID; 641627; -.
DR   KEGG; rno:641627; -.
DR   UCSC; RGD:1561378; rat.
DR   CTD; 244332; -.
DR   RGD; 1561378; Defb14.
DR   eggNOG; ENOG502TF5P; Eukaryota.
DR   GeneTree; ENSGT00530000064280; -.
DR   HOGENOM; CLU_189296_2_0_1; -.
DR   InParanoid; Q32ZH7; -.
DR   OMA; EQIGHCS; -.
DR   PhylomeDB; Q32ZH7; -.
DR   Reactome; R-RNO-1461957; Beta defensins.
DR   Reactome; R-RNO-1461973; Defensins.
DR   PRO; PR:Q32ZH7; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000032304; Expressed in esophagus and 8 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
DR   GO; GO:0060326; P:cell chemotaxis; ISO:RGD.
DR   GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR   GO; GO:0051873; P:killing by host of symbiont cells; ISO:RGD.
DR   GO; GO:0031640; P:killing of cells of another organism; ISO:RGD.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..67
FT                   /note="Beta-defensin 14"
FT                   /id="PRO_0000352699"
FT   DISULFID        33..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..63
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  7803 MW;  635E5983B9A77734 CRC64;
     MRLHYLLFVF LILFLVPAPG DTFIPKSLRR FFCRVRGGRC AILNCLGKEE QIGRCSNRGQ
     KCCRKKK