DFB15_MOUSE
ID DFB15_MOUSE Reviewed; 79 AA.
AC Q8R2I5; A2A4E5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Beta-defensin 15;
DE Short=BD-15;
DE Short=mBD-15;
DE AltName: Full=Defensin, beta 15;
DE Flags: Precursor;
GN Name=Defb15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6N; TISSUE=Testis;
RX PubMed=12644567; DOI=10.1093/molbev/msg060;
RA Morrison G.M., Semple C.A.M., Kilanowski F.M., Hill R.E., Dorin J.R.;
RT "Signal sequence conservation and mature peptide divergence within
RT subgroups of the murine beta-defensin gene family.";
RL Mol. Biol. Evol. 20:460-470(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Epididymis;
RX PubMed=14718547; DOI=10.1074/jbc.m307697200;
RA Zaballos A., Villares R., Albar J.P., Martinez-A C., Marquez G.;
RT "Identification on mouse chromosome 8 of new beta-defensin genes with
RT regionally specific expression in the male reproductive organ.";
RL J. Biol. Chem. 279:12421-12426(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and to a lesser extent in
CC epididymis (caput, corpus and cauda). Also weakly expressed in kidneys
CC and colon. {ECO:0000269|PubMed:14718547}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AJ437648; CAD26897.1; -; mRNA.
DR EMBL; AJ575428; CAE01401.1; -; mRNA.
DR EMBL; AL590619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS40288.1; -.
DR RefSeq; NP_631968.1; NM_139222.3.
DR AlphaFoldDB; Q8R2I5; -.
DR SMR; Q8R2I5; -.
DR STRING; 10090.ENSMUSP00000059763; -.
DR PaxDb; Q8R2I5; -.
DR PRIDE; Q8R2I5; -.
DR ProteomicsDB; 279635; -.
DR DNASU; 246082; -.
DR Ensembl; ENSMUST00000062586; ENSMUSP00000059763; ENSMUSG00000048500.
DR GeneID; 246082; -.
DR KEGG; mmu:246082; -.
DR UCSC; uc009lce.1; mouse.
DR CTD; 246082; -.
DR MGI; MGI:2179202; Defb15.
DR VEuPathDB; HostDB:ENSMUSG00000048500; -.
DR eggNOG; ENOG502TF62; Eukaryota.
DR GeneTree; ENSGT00950000183398; -.
DR HOGENOM; CLU_187814_0_0_1; -.
DR InParanoid; Q8R2I5; -.
DR OMA; RGTCKNN; -.
DR OrthoDB; 1629258at2759; -.
DR PhylomeDB; Q8R2I5; -.
DR BioGRID-ORCS; 246082; 1 hit in 52 CRISPR screens.
DR ChiTaRS; Defb15; mouse.
DR PRO; PR:Q8R2I5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R2I5; protein.
DR Bgee; ENSMUSG00000048500; Expressed in epididymal fat pad and 5 other tissues.
DR Genevisible; Q8R2I5; MM.
DR GO; GO:0019898; C:extrinsic component of membrane; ISO:MGI.
DR GO; GO:1990742; C:microvesicle; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0031727; F:CCR2 chemokine receptor binding; ISO:MGI.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0001530; F:lipopolysaccharide binding; ISO:MGI.
DR GO; GO:0061760; P:antifungal innate immune response; ISO:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..79
FT /note="Beta-defensin 15"
FT /id="PRO_0000006943"
FT DISULFID 26..53
FT /evidence="ECO:0000250"
FT DISULFID 33..47
FT /evidence="ECO:0000250"
FT DISULFID 37..54
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8730 MW; 5B04603D0E17787F CRC64;
MKTFLFLFAV LFFLDPAKNA FFDEKCSRVN GRCTASCLKN EELVALCQKN LKCCVTVQPC
GKSKSNQSDE GSGHMGTWG
