ID   DFB15_RAT               Reviewed;          79 AA.
AC   Q32ZH6;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Beta-defensin 15;
DE            Short=BD-15;
DE   AltName: Full=Defensin, beta 15;
DE   Flags: Precursor;
GN   Name=Defb15;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT51886.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY621347; AAT51886.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001032609.1; NM_001037520.1.
DR   AlphaFoldDB; Q32ZH6; -.
DR   SMR; Q32ZH6; -.
DR   STRING; 10116.ENSRNOP00000018375; -.
DR   PaxDb; Q32ZH6; -.
DR   GeneID; 641645; -.
DR   KEGG; rno:641645; -.
DR   UCSC; RGD:1563061; rat.
DR   CTD; 246082; -.
DR   RGD; 1563061; Defb15.
DR   eggNOG; ENOG502TF62; Eukaryota.
DR   InParanoid; Q32ZH6; -.
DR   OrthoDB; 1629258at2759; -.
DR   PhylomeDB; Q32ZH6; -.
DR   PRO; PR:Q32ZH6; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0019898; C:extrinsic component of membrane; ISO:RGD.
DR   GO; GO:1990742; C:microvesicle; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0031727; F:CCR2 chemokine receptor binding; ISO:RGD.
DR   GO; GO:0008201; F:heparin binding; ISO:RGD.
DR   GO; GO:0001530; F:lipopolysaccharide binding; ISO:RGD.
DR   GO; GO:0061760; P:antifungal innate immune response; ISO:RGD.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR   GO; GO:0045087; P:innate immune response; ISO:RGD.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..79
FT                   /note="Beta-defensin 15"
FT                   /id="PRO_0000352700"
FT   DISULFID        26..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  9040 MW;  CACBE0D110A0CF61 CRC64;
     MKTFLFLFAV FFFLDPAKNA FFDEKCSRIN GRCTESCLKN EELIALCQKN LKCCVTVQPC
     GRDKGDELDE DSGYNRTRG